Mapping cylinder

People are nonetheless rushing to buy properties in Singapore. A new residential condominium mission in Bedok had a long queue three days before its official launch and bought more than 350 units on the very first day. Nonetheless, there is a ‘development' that had emerged in 2011 that the majority have possibly overlooked.

In August, more than a hundred individuals across 16 states reportedly had been sickened with salmonella after consuming mangos In September, the Meals and Drug Administration detained mango imports from a Mexican packing house after the fruits had been linked to the sickenings Save Cash On Your Online Purchasing Make saving money when purchasing on-line a breeze with Bodge's favourite app, Invisible Hands. This helpful program does the price-checking analysis for you, and will warn you when a unique site has a better value - or let you realize that you have found the most effective deal. Watch Posted by Edison Foo September 29, 2013 HEARTH SALE!!! From only $9xx,000! We hope this listing will help launch your search for new properties in Singapore. It's unlawful to purchase ice cream after 6 pm, in Newark.

for a borrower with one or more excellent residential property loans3; and No SSD will be payable by the seller if the property is bought more than three years after it was bought. Non-extension of the Jan 2009 Funds assistance measures for the property market when the measures expire. Permitting up to 2 years of property tax deferral for land accepted for improvement. Lively secondary marketplace for easy exit of property investments. Curiosity on mortgage fee is tax deductible when the property is rented out. We've progressive property tax rates for residential properties- the higher the value of the residential property, the upper the tax charge. Why do I've to pay property tax on my house when I'm an onwer-occupier and not deriving rental earnings? Palacio Cluster Landed

After obtaining a Sale License (topic to authorities circumstances meant to guard individuals shopping for property in Singapore), he might www.rmmonline.com proceed to sell units in his growth. Funding in the property market of Singapore is likely one of the few investment choices the place utilizing the bank's cash could not be any easier. The power of expats, to make a down payment, leverage the capital and consequently improve total return on investment, is excessive in Singapore. PRs who own a HDB flat must sell their flat inside six months of buying a non-public residential property in Singapore. EVERLASTING residents (PRs) now face unprecedented limits on their skill to purchase property in Singapore. New Condo in 2013 March Foreigners are eligible for Singapore greenback mortgage loan. housing grant

Skilled property brokers in Singapore will assist the client and defend their interests throughout the acquisition, and will help safe the provide at the best possible price. The agents may even be sure that all paperwork are in order and that the vendor is the rightful proprietor of the property. Most of the property brokers share their databases with each other. Tuesday's measures come after the Monetary Authority of Singapore in June tightened rules on property loans, and closed loopholes that allowed some householders to circumvent loan restrictions and avoid paying levies when buying extra property. Contact us for a FREE housing loan analysis and to study concerning the newest mortgage to worth on Singapore housing loans. J Gateway Condominium (Bought Out) Oct, 2013

6. Completion of automotive park, roads and drains serving the housing project 5% 7. Notice of Vacant Possession (Upon obtaining Temporary Occupation Permit) The estimates given by SingaporeHousingLoan.SG's calculator are not quotations and are usually not binding in any way on SingaporeHousingLoan.sg or the consumer. The method of calculation does not exactly mirror that of which is being used by the individual monetary establishment and the data provided should be used as a information only. SingaporeHousingLoan.SG's calculator does not pre-qualify you for any housing loan from any monetary institution. Undercover Report Finds Unlawful Rat Meat Sold In London Market Unpasteurized Tempeh Linked To Salmonella Outbreak That Sickens 60 Hottest EC Launch in Sengkang!

BuyRentSingaporeProperty.com is dedicated in providing the newest residential launches, Developer's sales, new launches, resale, HIGH tasks and rental of properties in Singapore. Then there are new launch property condos in the mid-tier range. These are sometimes in the vicinity of the city fringe, in areas corresponding to Newton and Novena Tanjong Rhu. These new launch projects are popular due to their proximity to town heart, the place the enterprise and entertainment centers and all the amenities they provide, but they're usually cheaper than the City core region tasks. Why submit cheques to register for new property launches in Singapore? Riversails Apartment @ Higher Serangoon LakeVille @ Jurong Lakeside Condo by MCL Ferra Condo @ Leonie Hill

Allometry is the study of the relationship of body size to shape, anatomy, physiology and finally behaviour, first outlined by Otto Snell in 1892, D'Arcy Thompson in 1917 and Julian Huxley in 1932. Allometry is a well-known study, particularly in statistical shape analysis for its theoretical developments, as well as in biology for practical applications to the differential growth rates of the parts of a living organism's body. One application is in the study of various insect species (e.g., the Hercules Beetle), where a small change in overall body size can lead to an enormous and disproportionate increase in the dimensions of appendages such as legs, antennae, or horns. The relationship between the two measured quantities is often expressed as a power law:

$y=kx^{a}\,\!$ or in a logarithmic form: $\log y=a\log x+\log k\,\!$

where $a$ is the scaling exponent of the law. Methods for estimating this exponent from data use type 2 regressions such as major axis regression or reduced major axis regression as these account for the variation in both variables, contrary to least squares regression, which does not account for error variance in the independent variable (e.g., log body mass). Other methods include measurement error models and a particular kind of principal component analysis.

Allometry often studies shape differences in terms of ratios of the objects' dimensions. Two objects of different size but common shape will have their dimensions in the same ratio. Take, for example, a biological object that grows as it matures. Its size changes with age but the shapes are similar. Studies of ontogenetic allometry often use lizards or snakes as model organisms because they lack parental care after birth or hatching and because they exhibit a large range of body size between the juvenile and adult stage. Lizards often exhibit allometric changes during their ontogeny.

In addition to studies that focus on growth, allometry also examines shape variation among individuals of a given age (and sex), which is referred to as static allometry. Comparisons of species are used to examine interspecific or evolutionary allometry (see also Phylogenetic comparative methods).

Isometric scaling and geometric similarity

Isometric scaling occurs when proportional relationships are preserved as size changes during growth or over evolutionary time. An example is found in frogs — aside from a brief period during the few weeks after metamorphosis, frogs grow isometrically. Therefore, a frog whose legs are as long as its body will retain that relationship throughout its life, even if the frog itself increases in size tremendously.

Isometric scaling is governed by the square-cube law. An organism which doubles in length isometrically will find that the surface area available to it will increase fourfold, while its volume and mass will increase by a factor of eight. This can present problems for organisms. In the case of above, the animal now has eight times the biologically active tissue to support, but the surface area of its respiratory organs has only increased fourfold, creating a mismatch between scaling and physical demands. Similarly, the organism in the above example now has eight times the mass to support on its legs, but the strength of its bones and muscles is dependent upon their cross-sectional area, which has only increased fourfold. Therefore, this hypothetical organism would experience twice the bone and muscle loads of its smaller version. This mismatch can be avoided either by being "overbuilt" when small or by changing proportions during growth, called allometry.

Isometric scaling is often used as a null hypothesis in scaling studies, with 'deviations from isometry' considered evidence of physiological factors forcing allometric growth.

Allometric scaling

Allometric scaling is any change that deviates from isometry. A classic example is the skeleton of mammals, which becomes much more robust and massive relative to the size of the body as the body size increases. Allometry is often expressed in terms of a scaling exponent based on body mass, or body length (Snout-vent length, total length etc.). A perfectly isometrically scaling organism would see all volume-based properties change proportionally to the body mass, all surface area-based properties change with mass to the power 2/3, and all length-based properties change with mass to the 1/3 power. If, after statistical analyses, for example, a volume-based property was found to scale to mass to the 0.9 power, then this would be called "negative allometry", as the values are smaller than predicted by isometry. Conversely, if a surface area based property scales to mass to the 0.8 power, the values are higher than predicted by isometry and the organism is said to show "positive allometry". One example of positive allometry occurs among species of monitor lizards (family Varanidae), in which the limbs are relatively longer in larger-bodied species.

Determining if a system is scaling with allometry

To determine whether isometry or allometry is present, an expected relationship between variables needs to be determined to compare data to. This is important in determining if the scaling relationship in a dataset deviates from an expected relationship (such as those that follow isometry). The use of tools such as dimensional analysis is very helpful in determining expected slope. This ‘expected’ slope, as it is known, is essential for detecting allometry because scaling variables are comparisons to other things. Saying that mass scales with a slope of 5 in relation to length doesn’t have much meaning unless you know the isometric slope is 3, meaning in this case, the mass is increasing extremely fast. For example, different sized frogs should be able to jump the same distance according to the geometric similarity model proposed by Hill 1950 and interpreted by Wilson 2000, but in actuality larger frogs do jump longer distances. Dimensional analysis is extremely useful for balancing units in an equation or in our case, determining expected slope. A few dimensional examples below: M-Mass L-Length V-Volume (which is also L cubed because a volume is merely length cubed)

Allometric relations show as straight lines when plotted on double-logarithmic axes

If trying to find the expected slope for the relationship between mass and the characteristic length of an animal (see figure) you would take the units of mass (M=L³, because mass is a volume-volumes are lengths cubed) from the Y axis and divide them by the X axis (in this case L). Your expected slope on a double-logarithmic plot of L³/ L¹ in this case is 3 (log₁₀(L³)/log₁₀(L¹)=3). This is the slope of a straight line, but most data gathered in science does not automatically fall neatly in a straight line, so data transformations are useful. It is also important to keep in mind what you are comparing in your data. Comparing head length to head width can yield different results than comparing to body length. Sometimes a characteristic length such as head length may scale differently to its width than body length.

A common way to analyze data such as those collected in scaling is to use log-transformation. It is beneficial to transform both axes using logarithms and then perform a linear regression. This will normalize the data set and make it easier to analyze trends using the slope of the line. Before analyzing data though, it is important to have a predicted slope of the line to compare your analysis to. After data are log transformed and linearly regressed. You can then use least squares regression with 95% confidence intervals or reduced major axis analysis. Sometimes the two analyses can yield different results, but often they do not. If the expected slope is outside the confidence intervals then there is allometry present. If mass in our imaginary animal scaled with a slope of 5 and this was a statistically significant value, then mass would scale very fast in this animal versus the expected value. It would scale with positive allometry. If the expected slope is 3 and in reality in a certain organism mass scaled with 1 (assuming this slope is statistically significant), then it would be negatively allometric.

Another example: Force is dependent on the cross-sectional area of muscle (CSA), which is L². If comparing force to a length, then your expected slope is 2. Alternatively, this analysis may be accomplished with a power regression. Plot the relationship between your data onto a graph. Fit this to a power curve (depending on your stats program, this can be done multiple ways) and it will give you an equation with the form y=Zx^number. That “number” is the relationship between your data points. The downside to this form of analysis is that it makes it a little more difficult to do statistical analyses.

Physiological scaling

Many physiological and biochemical processes (such as heart rate, respiration rate or the maximum reproduction rate) show scaling, mostly associated with the ratio between surface area and mass (or volume) of the animal. The metabolic rate of an individual animal is also subject to scaling.

Metabolic rate and body mass

In plotting an animal's basal metabolic rate (BMR) against the animal's own body mass, a logarithmic straight line is obtained, indicating a power-law dependence. Overall metabolic rate in animals is generally accepted to show negative allometry, scaling to mass to a power ≈ 0.75, known as Kleiber's law, 1932. This means that larger-bodied species (e.g., elephants) have lower mass-specific metabolic rates and lower heart rates, as compared with smaller-bodied species (e.g., mice), this straight line is known as the "mouse to elephant curve". These relationships of metabolic rates, times, and internal structure have been explained as, "an elephant is approximately a blown-up gorilla, which is itself a blown-up mouse."

Max Kleiber contributed the following allometric equation for relating the BMR to the body mass of an animal. Statistical analysis of the intercept did not vary from 70 and the slope was not varied from 0.75, thus:

$\mathrm {Metabolic\ Rate} =70M^{0.75}$

where $M$ is body mass, and metabolic rate is measured in kcal per day.

Consequently the body mass itself can explain the majority of the variation in the BMR. In removing the concept of body mass, the taxonomy of the animal assumes a major role in the scaling of the BMR. The further speculation that environmental conditions play a role in BMR can only be properly investigated once the role of taxonomy is established. The challenge with this lies in the fact that a shared environment also indicates a common evolutionary history and thus a close taxonomic relationship. There are strides currently in research to overcome these hurdles, for example an analysis in muroid rodents, the mouse, hamster, and vole type, took into account taxonomy. Results revealed the hamster (warm dry habitat) had lowest BMR and the mouse (warm wet dense habitat) had the highest BMR. Larger organs could explain the high BMR groups, along with their higher daily energy needs. Analyses such as this demonstrate the physiological adaptations to environmental changes that animals undergo.

Energy metabolism is subjected to the scaling of an animal and can be overcome by an individual's body design. The metabolic scope for an animal is the ratio of resting and maximum rate of metabolism for that particular species as determined by oxygen consumption. Oxygen consumption V_O2 and maximum oxygen consumption VO2 max. Oxygen consumption in species that differ in body size and organ system dimensions show a similarity in their charted V_O2 distributions indicating that despite the complexity in their systems, there is a power law dependence of similarity; therefore, universal patterns are observed in diverse animal taxonomy.

Across a broad range of species, allometric relations are not necessarily linear on a log-log scale. For example, the maximal running speeds of mammals show a complicated relationship with body mass, and the fastest sprinters are of intermediate body size.

Allometric muscle characteristics

The muscle characteristics of animals are similar in a wide range of animal sizes, though muscle sizes and shapes can and often do vary depending on environmental constraints placed on them. The muscle tissue itself maintains its contractile characteristics and does not vary depending on the size of the animal. Physiological scaling in muscles affects the number of muscle fibers and their intrinsic speed to determine the maximum power and efficiency of movement in a given animal. The speed of muscle recruitment varies roughly in inverse proportion to the cube root of the animal’s weight, such as the intrinsic frequency of the sparrow’s flight muscle compared to that of a stork’s.

$\mathrm {freq} ={\frac {1}{\mathrm {mass} ^{1/3}}}$

For inter-species allometric relations related to such ecological variables as maximal reproduction rate, attempts have been made to explain scaling within the context of dynamic energy budget theory and the metabolic theory of ecology. However, such ideas have been less successful.

Allometry of legged locomotion

Methods of study

Allometry has been used to study patterns in locomotive principles across a broad range of species. Such research has been done in pursuit of a better understanding of animal locomotion, including the factors that different gaits seek to optimize. Allometric trends observed in extant animals have even been combined with evolutionary algorithms to form realistic hypotheses concerning the locomotive patterns of extinct species. These studies have been made possible by the remarkable similarities among disparate species’ locomotive kinematics and dynamics, “despite differences in morphology and size”.

Allometric study of locomotion involves the analysis of the relative sizes, masses, and limb structures of similarly shaped animals and how these features affect their movements at different speeds. Patterns are identified based on dimensionless Froude numbers, which incorporate measures of animals’ leg lengths, speed or stride frequency, and weight.

Alexander incorporates Froude-number analysis into his “dynamic similarity hypothesis” of gait patterns. Dynamically similar gaits are those between which there are constant coefficients that can relate linear dimensions, time intervals, and forces. In other words, given a mathematical description of gait A and these three coefficients, one could produce gait B, and vice versa. The hypothesis itself is as follows: “animals of different sizes tend to move in dynamically similar fashion whenever the ratio of their speed allows it.” While the dynamic similarity hypothesis may not be a truly unifying principle of animal gait patterns, it is a remarkably accurate heuristic.

It has also been shown that living organisms of all shapes and sizes utilize spring mechanisms in their locomotive systems, probably in order to minimize the energy cost of locomotion. The allometric study of these systems has fostered a better understanding of why spring mechanisms are so common, how limb compliance varies with body size and speed, and how these mechanisms affect general limb kinematics and dynamics.

Principles of legged locomotion identified through allometry

• Alexander found that animals of different sizes and masses traveling with the same Froude number consistently exhibit similar gait patterns.
• Duty factors—percentages of a stride during which a foot maintains contact with the ground—remain relatively constant for different animals moving with the same Froude number.
• The dynamic similarity hypothesis states that “animals of different sizes tend to move in dynamically similar fashion whenever the ratio of their speed allows it”.
• Body mass has even more of an effect than speed on limb dynamics.
• Leg stiffness, $\mathrm {k_{leg}} ={\frac {\mathrm {peak\ force} }{\mathrm {peak\ displacement} }}$, is proportional to $M^{0.67}$, where $M$ is body mass.
• Peak force experienced throughout a stride is proportional to $M^{0.97}$.
• The amount by which a leg shortens during a stride (i.e. its peak displacement) is proportional to $M^{0.30}$.
• The angle swept by a leg during a stride is proportional to $M^{-0.034}$.
• The mass-specific work rate of a limb is proportional to $M^{0.11}$.

Allometric scaling in fluid locomotion

This technical section is not well-written and needs editing.

The mass/density of organism has a large effect on organisms locomotion through a fluid. For example tiny organisms use flagella and can effectively move through a fluid it is suspended in. Then on the other scale a Blue Whale that is much more massive and dense in comparison with the viscosity of the fluid, compared to a bacterium in the same medium. The way in which the fluid interacts with the external boundaries of the organism is important with locomotion through the fluid. For streamlined swimmers the resistance or drag determines the performance of the organism. This drag or resistance can be seen in two distinct flow patterns. There is Laminar Flow where the fluid is relatively uninterrupted after the organism moves through it. Turbulent flow is the opposite, where the fluid moves roughly around an organisms that creates vortices that absorb energy from the propulsion or momentum of the organism. Scaling also affects locomotion through a fluid because of the energy needed to propel an organism and to keep up velocity through momentum. The rate of oxygen consumption per gram body size decreases consistently with increasing body size. (Knut Schmidt-Nielson 2004)

In general, smaller, more streamlined organisms create laminar flow (R<0.5x106), whereas larger, less streamlined organisms produce turbulent flow (R>2.0×106). Also, increase in velocity (V) increases turbulence, which can be proved using the Reynolds equation. In nature however, organisms such as a 6‘-6” dolphin moving at 15 knots does not have the appropriate Reynolds numbers for laminar flow R=107, but exhibit it in nature. Mr. G.A Steven observed and documented dolphins moving at 15 knots alongside his ship leaving a single trail of light when phosphorescent activity in the sea was high. The factors that contribute are:

• Surface area of the organism and its effect on the fluid in which the organism lives is very important in determining the parameters of locomotion.
• The Velocity of an organism through fluid changes the dynamic of the flow around that organism and as velocity increases the shape of the organism becomes more important for laminar flow.
• Density and viscosity of fluid.
• Length of the organism is factored into the equation because the surface area of just the front 2/3 of the organism has an effect on the drag

The resistance to the motion of an approximately stream-lined solid through a fluid can be expressed by the formula: C_fρ(total surface)V2/2
V = velocity
ρ = density of fluid
C_f = 1.33R-1 (laminar flow) R= Reynolds number

Reynolds number [R]=VL/ν
V = velocity
L = Axial length of organism
ν = kinematic viscosity (viscosity/density)

Notable Reynolds numbers:
R<0.5x106 = Laminar Flow threshold
R>2.0x106 = Turbulent Flow threshold

Scaling also has an effect on the performance of organisms in fluid. This is extremely important for marine mammals and other marine organisms that rely on atmospheric oxygen to survive and carry out respiration. This can affect how fast an organism can propel itself efficiently and more importantly how long it can dive, or how long and how deep an organism can stay underwater. Heart mass and lung volume are important in determining how scaling can affect metabolic function and efficiency. Aquatic mammals, like other mammals, have the same size heart proportional to their bodies.

Mammals have a heart that is about 0.6% of the total body mass across the board from a small mouse to a large Blue Whale. It can be expressed as: Heart Weight =0.006Mb1.0. Where Mb is the body mass of the individual. Lung volume is also directly related to body mass in mammals (slope = 1.02). The lung has a volume of 63 ml for every kg of body mass. In addition, the tidal volume at rest in an individual is 1/10 the lung volume. Also respiration costs with respect to oxygen consumption is scaled in the order of Mb.75. This shows that mammals, regardless of size, have the same size respiratory and cardiovascular systems and it turn have the same amount of blood: About 5.5% of body mass. This means that for a similarly designed marine mammals, the larger the individual the more efficiently they can travel compared to a smaller individual. It takes the same effort to move one body length whether the individual is one meter or ten meters. This can explain why large whales can migrate far distance in the oceans and not stop for rest. It is metabolically less expensive to be larger in body size. This goes for terrestrial and flying animals as well. In fact, for an organism to move any distance, regardless of type from elephants to centipedes, smaller animals consume more oxygen per unit body mass than larger. This metabolic advantage that larger animals have make it possible for larger marine mammals to dive for longer durations of time than their smaller counterparts. The fact that the heart rate is lower means that larger animals can carry more blood, which carries more oxygen. Then in conjuncture with the fact that mammals reparation costs scales in the order of Mb.75 shows how an advantage can be had in having a larger body mass. More simply, a larger whale can hold more oxygen and at the same time demand less metabolically than a smaller whale.

Traveling long distances and deep dives are a combination of good stamina and also moving an efficient speed and in an efficient way to create laminar flow, reducing drag and turbulence. In sea water as the fluid, it traveling long distances in large mammals, such as whales, is facilitated by the fact that they are neutrally buoyant and have their mass completely supported by the density of the sea water. On land animals have to expend a portion of their energy during locomotion to fight the effects of gravity.

It should be mentioned that flying organisms such as birds are also considered moving through a fluid. In scaling birds of similar shape it has also been seen that larger individuals have less metabolic cost per kg than smaller species. This would be expected because it holds true for every other form of animal. Birds also have a variance in wing beat frequency. Even with the compensation of larger wings per unit body mass, larger birds also have a slower wing beat frequency. This allows larger birds to fly at higher altitudes, longer distances, and faster absolute speeds than smaller birds. Because of the dynamics of lift-based locomotion and the fluid dynamics, birds have a U-shaped curve for metabolic cost and velocity. Because flight, in air as the fluid, is metabolically more costly at the lowest and the highest velocities. On the other end, small organisms such as insects can make gain advantage from the viscosity of the fluid (air) that they are moving in. A wing-beat timed perfectly can effectively uptake energy from the previous stroke. (Dickinson 2000) This form of wake capture allows an organism to recycle energy from the fluid or vortices within that fluid created by the organism itself. This same sort of wake capture occurs in aquatic organisms as well, and for organisms of all sizes. This dynamic of fluid locomotion allows smaller organisms gain advantage because the effect on them from the fluid is much greater because of there relatively smaller size.

Allometric engineering

Allometric engineering is a method for manipulating allometric relationships within or among groups.

Allometry in characteristics of a city

Arguing that there are a number of analogous concepts and mechanisms between cities and biological entities, Bettencourt et al. showed a number of scaling relationships between observable properties of a city and the city size. GDP, "supercreative" employment, number of inventors, crime, spread of disease, and even pedestrian walking speeds scale with city population.

Examples

Allometric law of cruising speed versus body mass

Some examples of allometric laws:

• Kleiber's law, metabolic rate $q_{0}$ is proportional to body mass $M$ raised to the $3/4$ power:

$q_{0}\sim M^{\frac {3}{4}}$

• breathing and heart rate $t$ are both proportional to body mass $M$ raised to the $1/4$ power:

$t\sim M^{\frac {1}{4}}$

• mass transfer contact area $A$ and body mass $M$:

$A\sim M^{\frac {7}{8}}$

• the proportionality between the optimal cruising speed $V_{opt}$ of flying bodies (insects, birds, airplanes) and body mass $M$ raised to the power $1/6$:

$V_{opt}\sim 30\cdot M^{\frac {1}{6}}[m\cdot s^{-1}]$

Determinants of size in different species

Many factors go into the determination of body mass and size for a given animal. These factors often affect body size on an evolutionary scale, but conditions such as availability of food and habitat size can act much more quickly on a species. Other examples include the following:

• Physiological design

Basic physiological design plays a role in the size of a given species. For example, animals with a closed circulatory system are larger than animals with open or no circulatory systems.

• Mechanical design

Mechanical design can also determine the maximum allowable size for a species. Animals with tubular endoskeletons tend to be larger than animals with exoskeletons or hydrostatic skeletons.

• Habitat

An animal’s habitat throughout its evolution is one of the largest determining factors in its size. On land, there is a positive correlation between body mass of the top species in the area and available land area. However, there are a much greater number of “small” species in any given area. This is most likely determined by ecological conditions, evolutionary factors, and the availability of food; a small population of large predators depend on a much greater population of small prey to survive. In an aquatic environment, the largest animals can grow to have a much greater body mass than land animals where gravitational weight constraints are a factor.

See also

Biomechanics Comparative physiology Constructal theory Evolutionary physiology

Metabolic theory of ecology Phylogenetic comparative methods Power law (also known as a scaling law) Rensch's rule

References

43 year old Petroleum Engineer Harry from Deep River, usually spends time with hobbies and interests like renting movies, property developers in singapore new condominium and vehicle racing. Constantly enjoys going to destinations like Camino Real de Tierra Adentro.

Further reading

• 20 year-old Real Estate Agent Rusty from Saint-Paul, has hobbies and interests which includes monopoly, property developers in singapore and poker. Will soon undertake a contiki trip that may include going to the Lower Valley of the Omo.
  
  My blog: http://www.primaboinca.com/view_profile.php?userid=5889534
• 20 year-old Real Estate Agent Rusty from Saint-Paul, has hobbies and interests which includes monopoly, property developers in singapore and poker. Will soon undertake a contiki trip that may include going to the Lower Valley of the Omo.
  
  My blog: http://www.primaboinca.com/view_profile.php?userid=5889534
• 20 year-old Real Estate Agent Rusty from Saint-Paul, has hobbies and interests which includes monopoly, property developers in singapore and poker. Will soon undertake a contiki trip that may include going to the Lower Valley of the Omo.
  
  My blog: http://www.primaboinca.com/view_profile.php?userid=5889534
• 20 year-old Real Estate Agent Rusty from Saint-Paul, has hobbies and interests which includes monopoly, property developers in singapore and poker. Will soon undertake a contiki trip that may include going to the Lower Valley of the Omo.
  
  My blog: http://www.primaboinca.com/view_profile.php?userid=5889534
• 20 year-old Real Estate Agent Rusty from Saint-Paul, has hobbies and interests which includes monopoly, property developers in singapore and poker. Will soon undertake a contiki trip that may include going to the Lower Valley of the Omo.
  
  My blog: http://www.primaboinca.com/view_profile.php?userid=5889534
• 20 year-old Real Estate Agent Rusty from Saint-Paul, has hobbies and interests which includes monopoly, property developers in singapore and poker. Will soon undertake a contiki trip that may include going to the Lower Valley of the Omo.
  
  My blog: http://www.primaboinca.com/view_profile.php?userid=5889534
• 20 year-old Real Estate Agent Rusty from Saint-Paul, has hobbies and interests which includes monopoly, property developers in singapore and poker. Will soon undertake a contiki trip that may include going to the Lower Valley of the Omo.
  
  My blog: http://www.primaboinca.com/view_profile.php?userid=5889534

External links

• FDA Guidance for Estimating Human Equivalent Dose (For "first in human" clinical trials of new drugs)