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| Name = RNA polymerase subunit kinase
| EC_number = 2.7.11.23
| CAS_number = 122097-00-1
| IUBMB_EC_number = 2/7/11/23
| GO_code = 0008353
| image =
| width =
| caption =
}}
In [[enzymology]], a '''[RNA-polymerase]-subunit kinase''' ({{EC number|2.7.11.23}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]
 
:ATP + [DNA-directed RNA polymerase] <math>\rightleftharpoons</math> ADP + phospho-[DNA-directed RNA polymerase]
 
Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[adenosine triphosphate|ATP]] and [[DNA-directed RNA polymerase]], whereas its two [[product (chemistry)|products]] are [[adenosine diphosphate|ADP]] and [[phospho-[DNA-directed RNA polymerase]]].
 
This enzyme belongs to the family of [[transferase]]s, specifically those transferring a phosphate group to the sidechain [[oxygen]] atom of [[serine]] or [[threonine]] residues in [[protein]]s ([[protein-serine/threonine kinase]]s). The systematic name of this enzyme class is '''ATP:[DNA-directed RNA polymerase] phosphotransferase'''. Other names in common use include '''CTD kinase''', and '''STK9'''.
 
==References==
{{reflist|1}}
* {{cite journal | author = Lee JM, Greenleaf AL | date = 1989 | title = A protein kinase that phosphorylates the C-terminal repeat domain of the largest subunit of RNA polymerase II | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 86 | pages = 3624&ndash;8  | pmid = 2657724 | doi = 10.1073/pnas.86.10.3624 | issue = 10 | pmc = 287190 }}
 
[[Category:EC 2.7.11]]
[[Category:Enzymes of unknown structure]]
 
{{enzyme-stub}}

Revision as of 02:36, 29 January 2014

Template:Enzyme In enzymology, a [RNA-polymerase]-subunit kinase (Air Transportation Experts Kull from Wingham, has many interests that include butterflies, property developers in singapore and digital photography. Is a travel freak and in recent past made buy a house in singapore journey to Paleochristian and Byzantine Monuments of Thessalonika.) is an enzyme that catalyzes the chemical reaction

ATP + [DNA-directed RNA polymerase] ADP + phospho-[DNA-directed RNA polymerase]

Thus, the two substrates of this enzyme are ATP and DNA-directed RNA polymerase, whereas its two products are ADP and [[phospho-[DNA-directed RNA polymerase]]].

This enzyme belongs to the family of transferases, specifically those transferring a phosphate group to the sidechain oxygen atom of serine or threonine residues in proteins (protein-serine/threonine kinases). The systematic name of this enzyme class is ATP:[DNA-directed RNA polymerase] phosphotransferase. Other names in common use include CTD kinase, and STK9.

References

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