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| {{Infobox enzyme
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| | Name = Glycosylphosphatidylinositol phospholipase D
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| | EC_number = 3.1.4.50
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| | CAS_number = 113756-14-2
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| | IUBMB_EC_number = 3/1/4/50
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| | GO_code =
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| '''Glycosylphosphatidylinositol phospholipase D''' ({{EC number|3.1.4.50}}, ''GPI-PLD'', ''glycoprotein phospholipase D'', ''phosphatidylinositol phospholipase D'', ''phosphatidylinositol-specific phospholipase D'') is an [[enzyme]] with system name ''glycoprotein-phosphatidylinositol phosphatidohydrolase''.<ref>{{cite journal | title = A phospholipase D specific for the phosphatidylinositol anchor of cell-surface proteins is abundant in plasma |author = Low, M.G. and Prasad, A.R.S. |journal = Proc. Natl. Acad. Sci. USA |year = 1988 |volume = 85 |pages = 980–984 |pmid = 3422494 | bibcode = 1988PNAS...85..980L | last2 = Prasad | doi = 10.1073/pnas.85.4.980 | issue = 4 | pmc = 279684}}</ref><ref>{{cite journal | title = Conversion of human placental alkaline phosphatase from a high ''M''<sub>r</sub> form to a low ''M''<sub>r</sub> form during butanol extraction. An investigation of the role of endogenous phosphoinositide-specific phospholipases |author = Malik, A.-S. and Low, M.G. |journal = Biochem. J. |year = 1986 |volume = 240 |pages = 519–527 |pmid = 3028377 | issue = 2 | pmc = 1147446}}</ref><ref>{{cite journal | title = Structural features of GPI-specific phospholipase D revealed by fragmentation and Ca<sup>2+</sup> binding studies |author = Li, J.Y., Hollfelder, K., Huang, K.S. and Low, M.G. |journal = J. Biol. Chem. |year = 1994 |volume = 269 |pages = 28963–28971 |pmid = 7961859 | issue = 46}}</ref><ref>{{cite journal | title = GPI-specific phospholipase D associates with an apoA-I- and apoA-IV-containing complex |author = Deeg, M.A, Vierman, E.L. and Cheung, M.C. |journal = J. Lipid Res. |year = 2001 |volume = 42 |pages = 442–451 |pmid = 11254757 | issue = 3}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]
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| : 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H<sub>2</sub>O <math>\rightleftharpoons</math> 6-(alpha-D-glucosaminyl)-1D-myo-inositol + 3-sn-phosphatidate
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| This enzyme cleaves proteins from the lipid part of the glycosylphosphatidylinositol (GPI) anchors.
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| == See also ==
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| * [[Phospholipase]]
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| == References ==
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| {{reflist}}
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| == External links ==
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| * {{MeshName|Glycosylphosphatidylinositol+phospholipase+D}}
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| [[Category:EC 3.1.4]]
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Latest revision as of 16:45, 26 August 2014
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