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{{enzyme
| Name = pyruvate oxidase
| EC_number = 1.2.3.3
| CAS_number = 9001-96-1
| IUBMB_EC_number = 1/2/3/3
| GO_code = 0047112
| image =
| width =
| caption =
}}
In [[enzymology]], a '''pyruvate oxidase''' ({{EC number|1.2.3.3}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]
 
:pyruvate + phosphate + O<sub>2</sub> <math>\rightleftharpoons</math> acetyl phosphate + CO<sub>2</sub> + H<sub>2</sub>O<sub>2</sub>
 
The 3 [[substrate (biochemistry)|substrates]] of this enzyme are [[pyruvate]], [[phosphate]], and [[oxygen|O<sub>2</sub>]], whereas its 3 [[product (chemistry)|products]] are [[acetyl phosphate]], [[carbon dioxide|CO<sub>2</sub>]], and [[hydrogen peroxide|H<sub>2</sub>O<sub>2</sub>]].
 
This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on the aldehyde or oxo group of donor with oxygen as acceptor. The systematic name of this enzyme class is '''pyruvate:oxygen 2-oxidoreductase (phosphorylating)'''. Other names in common use include '''pyruvic oxidase''', and '''phosphate-dependent pyruvate oxidase'''.  This enzyme participates in [[pyruvate metabolism]]. It has 2 [[cofactor (biochemistry)|cofactors]]: [[FAD]],  and [[Thiamin diphosphate]].
 
==Structural studies==
 
As of late 2007, 12 [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|1POW}}, {{PDB link|1POX}}, {{PDB link|1V5E}}, {{PDB link|1V5F}}, {{PDB link|1V5G}}, {{PDB link|1Y9D}}, {{PDB link|2DJI}}, {{PDB link|2EZ4}}, {{PDB link|2EZ8}}, {{PDB link|2EZ9}}, {{PDB link|2EZT}}, and {{PDB link|2EZU}}.
 
==References==
{{reflist|1}}
* {{cite journal | author = Williams FR, Hager LP | date = 1966 | title = Crystalline flavin pyruvate oxidase from Escherichia coli. I Isolation and properties of the flavoprotein | journal = Arch. Biochem. Biophys. | volume = 116 | pages = 168&ndash;76  | pmid = 5336022 | doi = 10.1016/0003-9861(66)90025-7 | issue = 1 }}
* {{cite journal | author = Tittmann K, Wille G, Golbik R, Weidner A, Ghisla S, Hubner G | date = 2005 | title = Radical phosphate transfer mechanism for the thiamin diphosphate- and FAD-dependent pyruvate oxidase from Lactobacillus plantarum Kinetic coupling of intercofactor electron transfer with phosphate transfer to acetyl-thiamin diphosphate via a transient FAD semiquinone/hydroxyethyl-ThDP radical pair | journal = Biochemistry. | volume = 44 | pages = 13291&ndash;303  | pmid = 16201755 | doi = 10.1021/bi051058z | issue = 40 }}
 
{{1.2-enzyme-stub}}
 
[[Category:EC 1.2.3]]
[[Category:Flavin enzymes]]
[[Category:Thiamin diphosphate enzymes]]
[[Category:Enzymes of known structure]]

Revision as of 03:53, 2 March 2013

Template:Enzyme In enzymology, a pyruvate oxidase (Air Transportation Experts Kull from Wingham, has many interests that include butterflies, property developers in singapore and digital photography. Is a travel freak and in recent past made buy a house in singapore journey to Paleochristian and Byzantine Monuments of Thessalonika.) is an enzyme that catalyzes the chemical reaction

pyruvate + phosphate + O2 acetyl phosphate + CO2 + H2O2

The 3 substrates of this enzyme are pyruvate, phosphate, and O2, whereas its 3 products are acetyl phosphate, CO2, and H2O2.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with oxygen as acceptor. The systematic name of this enzyme class is pyruvate:oxygen 2-oxidoreductase (phosphorylating). Other names in common use include pyruvic oxidase, and phosphate-dependent pyruvate oxidase. This enzyme participates in pyruvate metabolism. It has 2 cofactors: FAD, and Thiamin diphosphate.

Structural studies

As of late 2007, 12 structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, and Template:PDB link.

References

43 year old Petroleum Engineer Harry from Deep River, usually spends time with hobbies and interests like renting movies, property developers in singapore new condominium and vehicle racing. Constantly enjoys going to destinations like Camino Real de Tierra Adentro.

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    A vendor's stamp duty has been launched on industrial property for the primary time, at rates ranging from 5 per cent to 15 per cent. The Authorities might be trying to reassure the market that they aren't in opposition to foreigners and PRs investing in Singapore's property market. They imposed these measures because of extenuating components available in the market." The sale of new dual-key EC models will even be restricted to multi-generational households only. The models have two separate entrances, permitting grandparents, for example, to dwell separately. The vendor's stamp obligation takes effect right this moment and applies to industrial property and plots which might be offered inside three years of the date of buy. JLL named Best Performing Property Brand for second year running

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    There are various methods to go about discovering the precise property. Some local newspapers (together with the Straits Instances ) have categorised property sections and many local property brokers have websites. Now there are some specifics to consider when buying a 'new launch' rental. Intended use of the unit Every sale begins with 10 p.c low cost for finish of season sale; changes to 20 % discount storewide; follows by additional reduction of fiftyand ends with last discount of 70 % or extra. Typically there is even a warehouse sale or transferring out sale with huge mark-down of costs for stock clearance. Deborah Regulation from Expat Realtor shares her property market update, plus prime rental residences and houses at the moment available to lease Esparina EC @ Sengkang

Template:1.2-enzyme-stub