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| {{enzyme
| | Aboriginal and Torres Strait Islander Health Worker Stacey Dangerfield from Terence Bay, has interests for instance belly dancing, gas boiler and hot rods. Unearthed some amazing spots having spent 9 weeks at Chapada dos Veadeiros and Emas National Parks.<br><br>Here is my web site :: [http://www.skypixel.ir/profile/aufedler http://www.boilerrepairuk.co.uk/boiler-maintenance-in-fleetwood/] |
| | Name = leukotriene-C4 synthase
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| | EC_number = 4.4.1.20
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| | CAS_number = 90698-32-1
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| | IUBMB_EC_number = 4/4/1/20
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| | GO_code = 0004464
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| In [[enzymology]], a '''leukotriene-C4 synthase''' ({{EC number|4.4.1.20}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]
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| :leukotriene C<sub>4</sub> <math>\rightleftharpoons</math> leukotriene A<sub>4</sub> + glutathione
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| Hence, this enzyme has one [[substrate (biochemistry)|substrate]], [[leukotriene C4]], and two [[product (chemistry)|products]], [[leukotriene A4]] and [[glutathione]].
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| This enzyme belongs to the family of [[lyase]]s, specifically the class of carbon-sulfur lyases. The systematic name of this enzyme class is '''leukotriene-C4 glutathione-lyase (leukotriene-A4-forming)'''. Other names in common use include '''leukotriene C4 synthetase''', '''LTC4 synthase''', '''LTC4 synthetase''', '''leukotriene A4:glutathione S-leukotrienyltransferase''', '''(7E,9E,11Z,14Z)-(5S,6R)-5,6-epoxyicosa-7,9,11,14-''', '''tetraenoate:glutathione leukotriene-transferase''', '''(epoxide-ring-opening)''', '''(7E,9E,11Z,14Z)-(5S,6R)-6-(glutathion-S-yl)-5-hydroxyicosa-''', and '''7,9,11,14-tetraenoate glutathione-lyase (epoxide-forming)'''. This enzyme participates in [[arachidonic acid metabolism]].
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| ==Structural studies==
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| As of late 2007, 3 [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|2PNO}}, {{PDB link|2UUH}}, and {{PDB link|2UUI}}.
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| ==References==
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| {{reflist|1}}
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| * {{cite journal | author = Bach MK, Brashler JR, Morton DR Jr | date = 1984 | title = Solubilization and characterization of the leukotriene C4 synthetase of rat basophil leukemia cells: a novel, particulate glutathione S-transferase | journal = Arch. Biochem. Biophys. | volume = 230 | pages = 455–65 | pmid = 6324687 | doi = 10.1016/0003-9861(84)90426-0 | issue = 2 }}
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| * {{cite journal | author = Shimizu T | date = 1988 | title = Enzymes functional in the syntheses of leukotrienes and related compounds | journal = Int. J. Biochem. | volume = 20 | pages = 661–6 | pmid = 2846379 | doi = 10.1016/0020-711X(88)90160-7 | issue = 7 }}
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| * {{cite journal | author = Lam BK, Austen KF | date = 2002 | title = Leukotriene C4 synthase: a pivotal enzyme in cellular biosynthesis of the cysteinyl leukotrienes | journal = Prostaglandins. Other. Lipid. Mediat. | volume = 68-69 | pages = 511–20 | pmid = 12432940 | doi = 10.1016/S0090-6980(02)00052-7 }}
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| * {{cite journal | author = Christmas P, Weber BM, McKee M, Brown D, Soberman RJ | date = 2002 | title = Membrane localization and topology of leukotriene C4 synthase | journal = J. Biol. Chem. | volume = 277 | pages = 28902–8 | pmid = 12023288 | doi = 10.1074/jbc.M203074200 | issue = 32 }}
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| {{enzyme-stub}}
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| [[Category:EC 4.4.1]]
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| [[Category:Enzymes of known structure]]
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Aboriginal and Torres Strait Islander Health Worker Stacey Dangerfield from Terence Bay, has interests for instance belly dancing, gas boiler and hot rods. Unearthed some amazing spots having spent 9 weeks at Chapada dos Veadeiros and Emas National Parks.
Here is my web site :: http://www.boilerrepairuk.co.uk/boiler-maintenance-in-fleetwood/