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[[File:Alpha Decay.svg|thumb|240px|right|Visual representation of alpha decay]]
{{DEFAULTSORT:Acquired Immune Deficiency Syndrome}}
{{Nuclear physics}}
{{pp-move-indef}}
'''Alpha decay''', or α-decay, is a type of [[radioactivity|radioactive decay]] in which an [[atomic nucleus]] emits an [[alpha particle]] and thereby transforms (or 'decays') into an atom with a [[mass number]] 4 less and [[atomic number]] 2 less. For example, [[uranium-238]] decaying through α-particle emission to form [[thorium-234]] can be expressed as:<ref name="suchocki">Suchocki, John. ''Conceptual Chemistry'', 2007. Page 119.</ref>
{{ArticleHistory
|action1=PR
|action1date=March 12,2006
|action1link=Wikipedia:Peer review/AIDS/archive1
|action1oldid=43520162


:<math>\mathrm{~^{238}_{92}U}\rightarrow\mathrm{~^{234}_{90}Th} + {\alpha }</math>
|action2=FAC
|action2date=April 8,2006
|action2link=Wikipedia:Featured article candidates/AIDS/archive1
|action2result=promoted
|action2oldid=47663579


Because an [[alpha particle]] is the same as the nucleus of a [[helium-4]] atom - consisting of two [[proton]]s and two [[neutron]]s and thus having [[mass number]] 4 and [[atomic number]] 2 - this can also be written as:
|action3=FAR
|action3date=20:43, 18 May 2008
|action3link=Wikipedia:Featured article review/AIDS/archive1
|action3result=removed
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:<math>\mathrm{~^{238}_{92}U}\rightarrow\mathrm{~^{234}_{90}Th} + \mathrm{~^{4}_{2}He}</math>
|action4=GAN
|action4date=04:12, 6 August 2012
|action4link=Talk:HIV/AIDS/GA1
|action4result=listed
|action4oldid=505904299


Notice how, on either side of the nuclear equation, both the mass number and the atomic number are conserved: the mass number is 238 on the left side and (234 + 4) on the right side, and the atomic number is 92 on the left side and (90 + 2) on the right side.
|maindate=June 15,2006
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{{On this day|date1=2012-06-05|oldid1=496145338}}


The alpha particle also has a charge +2, but the charge is usually not written in nuclear equations, which describe nuclear reactions without considering the electrons. This convention is not meant to imply that the nuclei necessarily occur in neutral atoms. Alpha decay typically occurs in the heaviest nuclides. In theory it can occur only in nuclei somewhat heavier than nickel (element 28), where overall [[binding energy]] per [[nucleon]] is no longer a minimum, and the nuclides are therefore unstable toward spontaneous fission-type processes. In practice, this mode of decay has only been observed in nuclides considerably heavier than nickel, with the lightest known alpha emitter being the lightest [[isotope]]s (mass numbers 106–110) of [[tellurium]] (element 52).
{{Backwardscopy|title=Understanding and Management of Special Child in Pediatric Dentistry|url= http://books.google.ca/books?id=VAqP7xd4r74C&pg=PA264 |author= Gupta Priya| year=2012|org= JP Medical Ltd |comments=Extensive copy and pastes of large sections of Wikipedia without appropriate attribution or release under the appropriate license.}} 
{{Maintained|[[User talk:Jmh649|James Heilman, MD]]}} 


Alpha  decay is by far the most common form of [[cluster decay]] where the parent [[atom]] ejects a defined [[decay product|daughter]] collection of [[nucleon]]s, leaving another defined product behind (in [[nuclear fission]], a number of different pairs of daughters of approximately equal size are formed). Alpha decay is the most likely cluster decay because of the combined extremely high [[binding energy]] and relatively small mass of the helium-4 product nucleus (the alpha particle). Alpha decay, like other cluster decays, is fundamentally a [[quantum tunneling]] process. Unlike [[beta decay]], alpha decay is governed by the interplay between the [[nuclear force]] and the [[electromagnetic force]].
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[[Alpha particle]]s have a typical kinetic energy of 5&nbsp;MeV (that is, ≈&nbsp;0.13% of their total energy, i.e. 110&nbsp;TJ/kg) and a speed of 15,000&nbsp;km/s. This corresponds to a speed of around 0.05&nbsp;''[[Speed of light|c]]''. There is surprisingly small variation around this energy, due to the heavy dependence of the half-life of this process on the energy produced (see equations in the [[Geiger–Nuttall law]]). Because of their relatively large mass, +2 [[electric charge]] and relatively low velocity, alpha particles are very likely to interact with other atoms and lose their energy, so their forward motion is effectively stopped within a few centimeters of [[air]]. Most of the [[helium]] produced on [[Earth]] (approximately 99% of it) is the result of the alpha decay of underground deposits of [[mineral]]s containing [[uranium]] or [[thorium]]. The helium is brought to the surface as a byproduct of [[natural gas]] production.
==Lipodystrophy==
Do not see what part of the paper supports this "Those who have not been treated with HAART have a higher rates of these metabolic problems suggesting that HIV itself may have an negative impact on cardiovascular system.<ref>{{cite journal |author=Troll JG|title=Approach to dyslipidemia, lipodystrophy, and cardiovascular risk in patients with HIV infection|journal=Curr Atheroscler Rep |volume=13 |issue=1 |pages=51-6 |year=2011 |pmid=21181310  |pmc=3018260|doi=10.1007/s11883-010-0152-1}}</ref>"
{{reflist}}
[[User:Jmh649|<span style="color:#0000f1">'''Doc James'''</span>]] ([[User talk:Jmh649|talk]] · [[Special:Contributions/Jmh649|contribs]] · [[Special:EmailUser/Jmh649|email]]) (if I write on your page reply on mine) 16:10, 5 December 2013 (UTC)
:Emailed you the specifics and let you know via email/talk page. [[User:TylerDurden8823|TylerDurden8823]] ([[User talk:TylerDurden8823|talk]]) 20:43, 5 December 2013 (UTC)
 
== Semi-protected edit request on 22 December 2013 ==
 
{{edit semi-protected|<!-- Page to be edited -->|answered=yes}}
<!-- Begin request -->
I'd like to make an edit request:
 
under the section of "Discovery", I believe that Francoise Barre-Sinoussi should receive equal credit as Luc Montagnier in discovering HIV, as they received the Nobel Prize for it jointly.
 
 
Thank you.  <span style="font-size: smaller;" class="autosigned">— Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[Special:Contributions/147.26.87.13|147.26.87.13]] ([[User talk:147.26.87.13|talk]]) 02:18, 7 January 2014 (UTC)</span><!-- Template:Unsigned IP --> <!--Autosigned by SineBot-->
 
 
Hello,
 
In light of the new developments in our understanding of how HIV kills CD4 T cells
 
1. I would like to add these relevant references:
 
To the sentence: "It directly and indirectly destroys CD4+ T cells.[57]" please add <ref>http://www.cell.com/abstract/S0092-8674(10)01245-6</ref><ref>http://www.nature.com/nature/journal/vnfv/ncurrent/full/nature12940.html</ref>
 
2. To the section Pathophysiology I would request to add:
 
After the sentence: During the chronic phase, the consequences of generalized immune activation coupled with the gradual loss of the ability of the immune system to generate new T cells appear to account for the slow decline in CD4+ T cell numbers.[69]:
I would request to add the following sentences:
 
Recent studies<ref>http://www.nature.com/nature/journal/vnfv/ncurrent/full/nature12940.html</ref><ref>http://www.sciencemag.org/content/early/2013/12/18/science.1243640</ref> demonstrate that lymphoid CD4 T cells, abortively infected by HIV-1, die by caspase-1-mediated pyroptosis, a highly inflammatory form of programmed cell death. The DNA sensor IFI16 was shown to detect HIV DNA and triggers such cell death. Depletion of CD4 T-cell depletion and inflammation are signature events that propel HIV disease progression to AIDS. Cell death by pyroptosis appears to create a pathogenic vicious cycle in which dying CD4 T cells release inflammatory signals that attract more cells into the infected lymphoid tissues to die and to produce chronic inflammation and tissue injury.
 
Thank you, and Happy Holidays.
 
<!-- End request -->
[[Special:Contributions/71.135.167.64|71.135.167.64]] ([[User talk:71.135.167.64|talk]]) 21:34, 22 December 2013 (UTC)
::We typically use [[review articles]] rather than primary sources per [[WP:MEDRS]]. [[User:Jmh649|<span style="color:#0000f1">'''Doc James'''</span>]] ([[User talk:Jmh649|talk]] · [[Special:Contributions/Jmh649|contribs]] · [[Special:EmailUser/Jmh649|email]]) (if I write on your page reply on mine) 21:50, 22 December 2013 (UTC)
:[[File:Red information icon with gradient background.svg|20px|link=|alt=]] '''Not done:'''<!-- Template:ESp --> per above. --[[User:Mdann52|<span style="color:Green">'''Mdann'''</span>]][[Special:Contributions/Mdann52|<span style="color:Red">'''52'''</span>]]<small>[[User talk:Mdann52|<span style="color:Maroon">''talk to me!''</span>]]</small> 14:12, 6 January 2014 (UTC)
 
== Probable cure for AIDS ==
 
There's probably an experimental ''cure'' for AIDS, which is the [[stem cell]].
 
There is a news article saying that two men were functionally ''cured'' of AIDS while they were undergoing a [[stem cell therapy]] to treat their lymphomas. In July 2012, Henrich had reported that the two men had no HIVs at their blood.
 
Source: {{cite web|title=Two men "cured" of HIV no longer taking treatments|url=http://www.cbsnews.com/news/two-men-cured-of-hiv-no-longer-taking-treatments|first=Michelle|last=Castillo|website=CBS News|date=3 July 2013|accessdate=12 January 2014}}
 
[[Special:Contributions/112.198.90.25|112.198.90.25]] ([[User talk:112.198.90.25|talk]]) 09:24, 12 January 2014 (UTC)
::We use secondary sources. Yes interested but no not a general "cure" [[User:Jmh649|<span style="color:#0000f1">'''Doc James'''</span>]] ([[User talk:Jmh649|talk]] · [[Special:Contributions/Jmh649|contribs]] · [[Special:EmailUser/Jmh649|email]]) (if I write on your page reply on mine) 16:57, 12 January 2014 (UTC)
 
== AIDS Came from Eating Monkeys ==


==History==
Scientists from the University of Nottingham found that two strains of an HIV-like disease, SIV, has been discovered dormant in chimpanzees. Humans later caught the disease after hunting and eating the infected chimps. In humans, the disease morphed into HIV-AIDS, which reportedly has killed over 20 million people, mostly in Africa where eating monkey flesh often practiced <ref>http://www.thenazareneway.com/aids_came_from_monkeys.htm</ref>  <span style="font-size: smaller;" class="autosigned">— Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[Special:Contributions/195.5.27.63|195.5.27.63]] ([[User talk:195.5.27.63|talk]]) 14:07, 19 January 2014 (UTC)</span><!-- Template:Unsigned IP --> <!--Autosigned by SineBot-->
[[Image:Alphaspektroskopie.JPG|thumb|right|Alpha source beneath a radiation detector]]
Alpha particles were first described in the investigations of radioactivity by [[Ernest Rutherford]] in 1899, and by 1907 they were identified as He<sup>2+</sup> ions. For more details of this early work, see [[Alpha particle#History of discovery and use]].


By 1928, [[George Gamow]] had solved the theory of the alpha decay via tunneling. The alpha particle is trapped in a [[potential well]] by the nucleus. Classically, it is forbidden to escape, but according to the (then) newly discovered principles of [[quantum mechanics]], it has a tiny (but non-zero) probability of "[[quantum tunnelling|tunneling]]" through the [[potential barrier|barrier]] and appearing on the other side to escape the nucleus. Gamow solved a model potential for the nucleus and derived, from first principles, a relationship between the [[half-life]] of the decay, and the energy of the emission, which had been previously discovered empirically, and was known as the [[Geiger–Nuttall law]].<ref>[http://www.phy.uct.ac.za/courses/phy300w/np/ch1/node38.html For Gamow's derivation of this law, see]</ref>
== Lead ==
The lead says "AIDS is considered a pandemic", this should be rephrased as "HIV/AIDS is considered a pandemic", which is the expression that's also used in the given source. The point is that not all HIV-positive people will progress to AIDS. We should really be careful not to mix up the two terms in this article. Can someone change this please, as I am unable to edit the article. [[User:Chakalacka|Chakalacka]] ([[User talk:Chakalacka|talk]]) 18:05, 30 January 2014 (UTC)


==Uses==
{{done}} -- [[User:Scray|Scray]] ([[User talk:Scray|talk]]) 18:20, 30 January 2014 (UTC)
[[Americium-241]], an [[alpha emitter]], is used in [[smoke detector]]s. The alpha particles [[Ionization|ionize]] air in an open [[ion chamber]] and a small [[Electric current|current]] flows through the ionized air. Smoke particles from fire that enter the chamber reduce the current, triggering the smoke detector's alarm. ''See [[Smoke_detector#Ionization|Smoke_Detector-Ionization]] for details''.


Alpha decay can provide a safe power source for [[radioisotope thermoelectric generator]]s used for [[space probe]]s<ref>{{cite web |url=http://solarsystem.nasa.gov/rps/rtg.cfm |title=Radioisotope Thermoelectric Generator |work=Solar System Exploration |publisher=[[NASA]] |accessdate=25 March 2013}}</ref> and [[Artificial pacemaker|artificial heart pacemakers]].<ref>{{cite web |url=http://osrp.lanl.gov/pacemakers.shtml |title=Nuclear-Powered Cardiac Pacemakers |work=Off-Site Source Recovery Project |publisher=[[Los Alamos National Laboratory|LANL]] |accessdate=25 March 2013}}</ref> Alpha decay is much more easily shielded against than other forms of radioactive decay. [[Plutonium-238]], for example, requires only 2.5 millimetres of [[lead]] shielding to protect against unwanted radiation.{{cn|date=March 2014}}
::Since we are already at it, this sentence in the Virology section should also be fixed: "HIV is the cause of the spectrum of disease known as HIV/AIDS.". It just doesn't make sense. Maybe "HIV is the cause of the disease known as AIDS." or perhaps "HIV is the cause of a spectrum of diseases known as AIDS." [[User:Chakalacka|Chakalacka]] ([[User talk:Chakalacka|talk]]) 18:38, 30 January 2014 (UTC)
:::There is also "acute HIV" which is a disease caused by the HIV virus. So I think it is okay the way it is. The spectrum is HIV/AIDS. [[User:Jmh649|<span style="color:#0000f1">'''Doc James'''</span>]] ([[User talk:Jmh649|talk]] · [[Special:Contributions/Jmh649|contribs]] · [[Special:EmailUser/Jmh649|email]]) (if I write on your page reply on mine) 18:46, 30 January 2014 (UTC)
::::Has "acute HIV" actually been characterized/defined as a disease? I'm not a doc but I am wondering. Either way, I feel that the current sentence in a nutshell says "HIV is the cause of HIV" and somehow that seems more confusing than clarifying. [[User:Chakalacka|Chakalacka]] ([[User talk:Chakalacka|talk]]) 13:09, 31 January 2014 (UTC)
:::::Yes it is a disease. [[User:Jmh649|<span style="color:#0000f1">'''Doc James'''</span>]] ([[User talk:Jmh649|talk]] · [[Special:Contributions/Jmh649|contribs]] · [[Special:EmailUser/Jmh649|email]]) (if I write on your page reply on mine) 14:40, 31 January 2014 (UTC)


[[Static eliminator]]s typically use [[polonium-210]], an alpha emitter, to ionize air, allowing the 'static cling' to more rapidly dissipate.
== Semi-protected edit request on 31 January 2014 ==


==Toxicity==
{{Edit semi-protected|<!-- Page to be edited -->|answered=yes}}
Being relatively heavy and positively charged, alpha particles tend to have a very short [[mean free path]], and quickly lose kinetic energy within a short distance of their source. This results in several [[MeV]] being deposited in a relatively small volume of material. This increases the chance of cellular damage in cases of internal contamination. In general, external alpha radiation is not harmful since alpha particles are effectively shielded by a few centimeters of air, a piece of paper, or the thin layer of dead skin cells that make up the [[epidermis (skin)|epidermis]]. Even touching an alpha source is typically not harmful, though many alpha sources also are accompanied by [[beta decay|beta-emitting]] radio daughters, and alpha emission is also accompanied by gamma photon emission. If substances emitting alpha particles are ingested, inhaled, injected or introduced through the skin, then it could result in a measurable [[Equivalent dose|dose]].
<!-- Begin request -->


The [[relative biological effectiveness]] (RBE) of alpha radiation is higher than that of beta or gamma radiation. RBE quantifies the ability of radiation to cause certain biological effects, notably either [[cancer]] or [[necrosis|cell-death]], for equivalent radiation exposure. The higher value for alpha radiation is generally attributable to the high [[linear energy transfer]] (LET) coefficient, which is about one ionization of a chemical bond for every [[angstrom]] of travel by the alpha particle. The RBE has been set at the value of 20 for alpha radiation by various government regulations. The RBE is set at 10 for [[neutron]] irradiation, and at 1 for [[Beta decay|beta radiation]] and ionizing photons.
<!-- End request -->
[[Special:Contributions/27.124.18.34|27.124.18.34]] ([[User talk:27.124.18.34|talk]]) 13:48, 31 January 2014 (UTC)


However, another component of alpha radiation is the [[recoil]] of the parent nucleus, termed alpha recoil. Due to the [[conservation of momentum]] requiring the parent nucleus to recoil, the effect acts much like the 'kick' of a rifle butt when a bullet goes in the opposite direction. This gives a significant amount of energy to the recoiling nucleus, which also causes ionization damage (see [[ionizing radiation]]). The total energy of the recoil nucleus is readily calculable, and is roughly the weight of the alpha (4&nbsp;[[Atomic mass unit|u]]) divided by the weight of the parent (typically about 200&nbsp;u) times the total energy of the alpha. By some estimates, this might account for most of the internal radiation damage, as the recoil nuclei are typically [[heavy metal (chemistry)|heavy metals]] which preferentially collect on the [[chromosome]]s. In some studies,<ref>
:What actually? [[User:Noteswork|Noteswork]] ([[User talk:Noteswork|talk]]) 13:51, 31 January 2014 (UTC)
{{cite journal
|author=Winters TH, Franza JR
|year=1982
|title=Radioactivity in Cigarette Smoke
|journal=[[New England Journal of Medicine]]
|volume=306 |issue=6 |pages=364–365
|doi=10.1056/NEJM198202113060613
}}</ref> this has resulted in a RBE approaching 1,000 instead of the value used in governmental regulations.


The largest natural contributor to public radiation dose is [[radon]], a naturally occurring, radioactive gas found in soil and rock.<ref>[http://www.ans.org/pi/resources/dosechart/ ANS : Public Information : Resources : Radiation Dose Chart<!-- Bot generated title -->]</ref> If the gas is inhaled, some of the radon particles may attach to the inner lining of the lung. These particles continue to decay, emitting alpha particles which can damage cells in the lung tissue.<ref>EPA Radiation Information: Radon. October 6, 2006, [http://www.epa.gov/radiation/radionuclides/radon.htm], Accessed December 6, 2006</ref> The death of [[Marie Curie]] at age 66 from [[leukemia]] was probably caused by prolonged exposure to high doses of ionizing radiation, but it is not clear if this was due to alpha radiation or X-rays. Curie worked extensively with radium, which decays into radon,<ref>Health Physics Society, "Did Marie Curie die of a radiation overexposure?" [http://www.hps.org/publicinformation/ate/q535.html]</ref> along with other radioactive materials that emit [[beta decay|beta]] and [[gamma ray]]s. However, Curie also worked with unshielded X-ray tubes during World War I, and analysis of her skeleton during a reburial showed a relatively low level of radioisotope burden.
== "These" versus "The vast majority of these" ==


Russian dissident [[Alexander Litvinenko]]'s 2006 murder by [[radiation poisoning]] is thought to have been carried out with [[polonium-210]], an alpha emitter.
Disagreement with [https://en.wikipedia.org/w/index.php?title=HIV/AIDS&curid=5069516&diff=594374423&oldid=593841565 this edit] that I wanted to discuss rather than just revert.  


== See also ==
The full phrase in question, with the disputed part bolded, is:<blockquote>A small group of individuals continue to dispute the connection between HIV and AIDS,[228] the existence of HIV itself, or the validity of HIV testing and treatment methods.[229][230] '''The vast majority of these claims''', known as AIDS denialism, have been examined and rejected by the scientific community.</blockquote>
*[[Alpha particle]]
As it looks now, it is implied that there exist some disputes about HIV and its relationship with AIDS that have been examined and accepted. This is most certainly not the case: EVERY such denialist claim that has been investigated has been rejected, quite firmly. While "These claims" is technically imprecise, it does not give a false impression and is significantly more correct. Thoughts? [[User:TechBear|<font color="green">'''TechBear'''</font>]] &#124; [[User talk:TechBear|Talk]] &#124; [[Special:Contributions/TechBear|Contributions]] 15:06, 7 February 2014 (UTC)
*[[Beta decay]]
:I reverted it to say that all denialist claims are answered. There are not any [[WP:RS|reliable sources]] presenting unanswered denialist claims. There is no controversy in the scientific or medical community. Anyone who wishes to state otherwise should present a source making a claim which has not been answered. So far as I know, by the late 1990s the debates had resolved in the scientific and medical communities, and no claims have been made since then. See [[WP:MEDRS|Wikipedia's guide to reliable sources for medicine]] for information about how to present medical claims. [[User:Bluerasberry|<span style="background:#cedff2;color:#11e">''' Blue Rasberry '''</span>]][[User talk:Bluerasberry|<span style="cursor:help"><span style="background:#cedff2;color:#11e">(talk)</span></span>]] 15:49, 7 February 2014 (UTC)
::What we had before which was "These claims" was perfectly clear. Thus restored to that. [[User:Jmh649|<span style="color:#0000f1">'''Doc James'''</span>]] ([[User talk:Jmh649|talk]] · [[Special:Contributions/Jmh649|contribs]] · [[Special:EmailUser/Jmh649|email]]) (if I write on your page reply on mine) 18:03, 7 February 2014 (UTC)


==References==
== Removing very odd opinion from lead. ==
{{reflist}}
 
*[http://www.ct.infn.it/~rivel/Didat/SilDet.pdf Alpha emitters by increasing energy (Appendix 1)]
People are free to their opinions but I don't think they are needed in this Wikipedia article.  I will be removing the line "The disease has also become subject to many controversies involving religion." Considering most people on the planet are religious, and most have different views of all subject matter, anything could be "subject to many controversies involving religion".[[User:Mantion|Mantion]] ([[User talk:Mantion|talk]]) 06:00, 10 February 2014 (UTC)
:It's not an opinion or odd, and it's in the lead because it summarizes significant aspects of the article...per [[WP:Lead]]. [[User:Flyer22|Flyer22]] ([[User talk:Flyer22|talk]]) 06:05, 10 February 2014 (UTC)
::Yes there have been some controversies revolving around organized religion. [[User:Jmh649|<span style="color:#0000f1">'''Doc James'''</span>]] ([[User talk:Jmh649|talk]] · [[Special:Contributions/Jmh649|contribs]] · [[Special:EmailUser/Jmh649|email]]) (if I write on your page reply on mine) 10:14, 10 February 2014 (UTC)


== External links ==
== Congenital HIV/AIDS infection ==
* [[Image:Ndslivechart.png]] '''[http://www-nds.iaea.org/livechart The LIVEChart of Nuclides - IAEA ]''' with filter on alpha decay
* [http://nagysandor.eu/AsimovTeka/AlphaExamples/index_en.html Alpha decay with 3 animated examples] showing the recoil of daughter


{{Nuclear processes}}
No article on it. Surprised. Anyone smart?
:How, exactly, does a newborn with HIV differ substantially from someone who contracts the virus later in life? Can you refer editors to [[WP:RS|reliable]], [[WP:3PARTY|third-party]] sources that detail the differences? [[User:TechBear|<font color="green">'''TechBear'''</font>]] &#124; [[User talk:TechBear|Talk]] &#124; [[Special:Contributions/TechBear|Contributions]] 22:16, 12 February 2014 (UTC)


{{DEFAULTSORT:Alpha Decay}}
==Red ribbon==
[[Category:Nuclear physics]]
Consider it a better image for the lead. Thus restored. [[User:Jmh649|<span style="color:#0000f1">'''Doc James'''</span>]] ([[User talk:Jmh649|talk]] · [[Special:Contributions/Jmh649|contribs]] · [[Special:EmailUser/Jmh649|email]]) (if I write on your page reply on mine) 19:02, 27 February 2014 (UTC)
[[Category:Radioactivity]]

Revision as of 17:24, 19 August 2014

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Template:Backwardscopy Template:Maintained

Template:Archives User:ClueBot III/ArchiveThis User:HBC Archive Indexerbot/OptIn

Lipodystrophy

Do not see what part of the paper supports this "Those who have not been treated with HAART have a higher rates of these metabolic problems suggesting that HIV itself may have an negative impact on cardiovascular system.[1]" 43 year old Petroleum Engineer Harry from Deep River, usually spends time with hobbies and interests like renting movies, property developers in singapore new condominium and vehicle racing. Constantly enjoys going to destinations like Camino Real de Tierra Adentro. Doc James (talk · contribs · email) (if I write on your page reply on mine) 16:10, 5 December 2013 (UTC)

Emailed you the specifics and let you know via email/talk page. TylerDurden8823 (talk) 20:43, 5 December 2013 (UTC)

Semi-protected edit request on 22 December 2013

Template:Edit semi-protected I'd like to make an edit request:

under the section of "Discovery", I believe that Francoise Barre-Sinoussi should receive equal credit as Luc Montagnier in discovering HIV, as they received the Nobel Prize for it jointly.


Thank you. — Preceding unsigned comment added by 147.26.87.13 (talk) 02:18, 7 January 2014 (UTC)


Hello,

In light of the new developments in our understanding of how HIV kills CD4 T cells

1. I would like to add these relevant references:

To the sentence: "It directly and indirectly destroys CD4+ T cells.[57]" please add [2][3]

2. To the section Pathophysiology I would request to add:

After the sentence: During the chronic phase, the consequences of generalized immune activation coupled with the gradual loss of the ability of the immune system to generate new T cells appear to account for the slow decline in CD4+ T cell numbers.[69]: I would request to add the following sentences:

Recent studies[4][5] demonstrate that lymphoid CD4 T cells, abortively infected by HIV-1, die by caspase-1-mediated pyroptosis, a highly inflammatory form of programmed cell death. The DNA sensor IFI16 was shown to detect HIV DNA and triggers such cell death. Depletion of CD4 T-cell depletion and inflammation are signature events that propel HIV disease progression to AIDS. Cell death by pyroptosis appears to create a pathogenic vicious cycle in which dying CD4 T cells release inflammatory signals that attract more cells into the infected lymphoid tissues to die and to produce chronic inflammation and tissue injury.

Thank you, and Happy Holidays.

71.135.167.64 (talk) 21:34, 22 December 2013 (UTC)

We typically use review articles rather than primary sources per WP:MEDRS. Doc James (talk · contribs · email) (if I write on your page reply on mine) 21:50, 22 December 2013 (UTC)
Not done: per above. --Mdann52talk to me! 14:12, 6 January 2014 (UTC)

Probable cure for AIDS

There's probably an experimental cure for AIDS, which is the stem cell.

There is a news article saying that two men were functionally cured of AIDS while they were undergoing a stem cell therapy to treat their lymphomas. In July 2012, Henrich had reported that the two men had no HIVs at their blood.

Source: Template:Cite web

112.198.90.25 (talk) 09:24, 12 January 2014 (UTC)

We use secondary sources. Yes interested but no not a general "cure" Doc James (talk · contribs · email) (if I write on your page reply on mine) 16:57, 12 January 2014 (UTC)

AIDS Came from Eating Monkeys

Scientists from the University of Nottingham found that two strains of an HIV-like disease, SIV, has been discovered dormant in chimpanzees. Humans later caught the disease after hunting and eating the infected chimps. In humans, the disease morphed into HIV-AIDS, which reportedly has killed over 20 million people, mostly in Africa where eating monkey flesh often practiced [6] — Preceding unsigned comment added by 195.5.27.63 (talk) 14:07, 19 January 2014 (UTC)

Lead

The lead says "AIDS is considered a pandemic", this should be rephrased as "HIV/AIDS is considered a pandemic", which is the expression that's also used in the given source. The point is that not all HIV-positive people will progress to AIDS. We should really be careful not to mix up the two terms in this article. Can someone change this please, as I am unable to edit the article. Chakalacka (talk) 18:05, 30 January 2014 (UTC)

Template:Done -- Scray (talk) 18:20, 30 January 2014 (UTC)

Since we are already at it, this sentence in the Virology section should also be fixed: "HIV is the cause of the spectrum of disease known as HIV/AIDS.". It just doesn't make sense. Maybe "HIV is the cause of the disease known as AIDS." or perhaps "HIV is the cause of a spectrum of diseases known as AIDS." Chakalacka (talk) 18:38, 30 January 2014 (UTC)
There is also "acute HIV" which is a disease caused by the HIV virus. So I think it is okay the way it is. The spectrum is HIV/AIDS. Doc James (talk · contribs · email) (if I write on your page reply on mine) 18:46, 30 January 2014 (UTC)
Has "acute HIV" actually been characterized/defined as a disease? I'm not a doc but I am wondering. Either way, I feel that the current sentence in a nutshell says "HIV is the cause of HIV" and somehow that seems more confusing than clarifying. Chakalacka (talk) 13:09, 31 January 2014 (UTC)
Yes it is a disease. Doc James (talk · contribs · email) (if I write on your page reply on mine) 14:40, 31 January 2014 (UTC)

Semi-protected edit request on 31 January 2014

Template:Edit semi-protected

27.124.18.34 (talk) 13:48, 31 January 2014 (UTC)

What actually? Noteswork (talk) 13:51, 31 January 2014 (UTC)

"These" versus "The vast majority of these"

Disagreement with this edit that I wanted to discuss rather than just revert.

The full phrase in question, with the disputed part bolded, is:

A small group of individuals continue to dispute the connection between HIV and AIDS,[228] the existence of HIV itself, or the validity of HIV testing and treatment methods.[229][230] The vast majority of these claims, known as AIDS denialism, have been examined and rejected by the scientific community.

As it looks now, it is implied that there exist some disputes about HIV and its relationship with AIDS that have been examined and accepted. This is most certainly not the case: EVERY such denialist claim that has been investigated has been rejected, quite firmly. While "These claims" is technically imprecise, it does not give a false impression and is significantly more correct. Thoughts? TechBear | Talk | Contributions 15:06, 7 February 2014 (UTC)

I reverted it to say that all denialist claims are answered. There are not any reliable sources presenting unanswered denialist claims. There is no controversy in the scientific or medical community. Anyone who wishes to state otherwise should present a source making a claim which has not been answered. So far as I know, by the late 1990s the debates had resolved in the scientific and medical communities, and no claims have been made since then. See Wikipedia's guide to reliable sources for medicine for information about how to present medical claims. Blue Rasberry (talk) 15:49, 7 February 2014 (UTC)
What we had before which was "These claims" was perfectly clear. Thus restored to that. Doc James (talk · contribs · email) (if I write on your page reply on mine) 18:03, 7 February 2014 (UTC)

Removing very odd opinion from lead.

People are free to their opinions but I don't think they are needed in this Wikipedia article. I will be removing the line "The disease has also become subject to many controversies involving religion." Considering most people on the planet are religious, and most have different views of all subject matter, anything could be "subject to many controversies involving religion".Mantion (talk) 06:00, 10 February 2014 (UTC)

It's not an opinion or odd, and it's in the lead because it summarizes significant aspects of the article...per WP:Lead. Flyer22 (talk) 06:05, 10 February 2014 (UTC)
Yes there have been some controversies revolving around organized religion. Doc James (talk · contribs · email) (if I write on your page reply on mine) 10:14, 10 February 2014 (UTC)

Congenital HIV/AIDS infection

No article on it. Surprised. Anyone smart?

How, exactly, does a newborn with HIV differ substantially from someone who contracts the virus later in life? Can you refer editors to reliable, third-party sources that detail the differences? TechBear | Talk | Contributions 22:16, 12 February 2014 (UTC)

Red ribbon

Consider it a better image for the lead. Thus restored. Doc James (talk · contribs · email) (if I write on your page reply on mine) 19:02, 27 February 2014 (UTC)

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  2. ↑ http://www.cell.com/abstract/S0092-8674(10)01245-6
  3. ↑ http://www.nature.com/nature/journal/vnfv/ncurrent/full/nature12940.html
  4. ↑ http://www.nature.com/nature/journal/vnfv/ncurrent/full/nature12940.html
  5. ↑ http://www.sciencemag.org/content/early/2013/12/18/science.1243640
  6. ↑ http://www.thenazareneway.com/aids_came_from_monkeys.htm
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