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{{enzyme
This is a preview for the new '''MathML rendering mode''' (with SVG fallback), which is availble in production for registered users.
| Name = Anthranilate Synthase 1i1q
[[File:Anthranilate Synthase 1i1q.png|thumb|right|One of many anthranilate synthase structures.]]
| EC_number = 4.1.3.27
| CAS_number = 9031-59-8
| IUBMB_EC_number = 4/1/3/27
| GO_code = 0004049
| image =
| width =
| caption =
}}
In [[enzymology]], an '''anthranilate synthase''' ({{EC number|4.1.3.27}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]


:chorismate + L-glutamine <math>\rightleftharpoons</math> anthranilate + pyruvate + L-glutamate 2
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Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[chorismate]] and [[L-glutamine]], whereas its 3 [[product (chemistry)|products]] are [[anthranilate]], [[pyruvate]], and [[L-glutamate]].
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==Function==
'''MathML'''
:<math forcemathmode="mathml">E=mc^2</math>


{{Empty section|date=November 2013}}
<!--'''PNG'''  (currently default in production)
:<math forcemathmode="png">E=mc^2</math>


==Reaction==
'''source'''
In [[enzymology]], an '''anthranilate synthase''' ({{EC number|4.1.3.27}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]
:<math forcemathmode="source">E=mc^2</math> -->
: chorismate + L-glutamine <math>\rightleftharpoons</math> anthranilate + pyruvate + L-glutamate
[[File:Reaction Paint.png|thumb|right|Chemical equation of reaction occurring in anthranilate synthase]]
Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[chorismate]] and [[L-glutamine]], whereas its 3 [[product (chemistry)|products]] are [[anthranilate]], [[pyruvate]], and [[L-glutamate]].


==Homologs==
<span style="color: red">Follow this [https://en.wikipedia.org/wiki/Special:Preferences#mw-prefsection-rendering link] to change your Math rendering settings.</span> You can also add a [https://en.wikipedia.org/wiki/Special:Preferences#mw-prefsection-rendering-skin Custom CSS] to force the MathML/SVG rendering or select different font families. See [https://www.mediawiki.org/wiki/Extension:Math#CSS_for_the_MathML_with_SVG_fallback_mode these examples].


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==Demos==


==Paralogs==
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==Nomenclature==
* accessibility:
This enzyme belongs to the family of [[lyase]]s, to be specific the oxo-acid-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is '''chorismate pyruvate-lyase (amino-accepting; anthranilate-forming)'''. Other names in common use include '''anthranilate synthetase''', '''chorismate lyase''', and '''chorismate pyruvate-lyase (amino-accepting)'''. This enzyme participates in [[phenylalanine, tyrosine and tryptophan biosynthesis]] and [[two-component system - general]].
** Safari + VoiceOver: [https://commons.wikimedia.org/wiki/File:VoiceOver-Mac-Safari.ogv video only], [[File:Voiceover-mathml-example-1.wav|thumb|Voiceover-mathml-example-1]], [[File:Voiceover-mathml-example-2.wav|thumb|Voiceover-mathml-example-2]], [[File:Voiceover-mathml-example-3.wav|thumb|Voiceover-mathml-example-3]], [[File:Voiceover-mathml-example-4.wav|thumb|Voiceover-mathml-example-4]], [[File:Voiceover-mathml-example-5.wav|thumb|Voiceover-mathml-example-5]], [[File:Voiceover-mathml-example-6.wav|thumb|Voiceover-mathml-example-6]], [[File:Voiceover-mathml-example-7.wav|thumb|Voiceover-mathml-example-7]]
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** NVDA+MathPlayer: [[File:Nvda-mathml-example-1.wav|thumb|Nvda-mathml-example-1]], [[File:Nvda-mathml-example-2.wav|thumb|Nvda-mathml-example-2]], [[File:Nvda-mathml-example-3.wav|thumb|Nvda-mathml-example-3]], [[File:Nvda-mathml-example-4.wav|thumb|Nvda-mathml-example-4]], [[File:Nvda-mathml-example-5.wav|thumb|Nvda-mathml-example-5]], [[File:Nvda-mathml-example-6.wav|thumb|Nvda-mathml-example-6]], [[File:Nvda-mathml-example-7.wav|thumb|Nvda-mathml-example-7]].
** Orca: There is ongoing work, but no support at all at the moment [[File:Orca-mathml-example-1.wav|thumb|Orca-mathml-example-1]], [[File:Orca-mathml-example-2.wav|thumb|Orca-mathml-example-2]], [[File:Orca-mathml-example-3.wav|thumb|Orca-mathml-example-3]], [[File:Orca-mathml-example-4.wav|thumb|Orca-mathml-example-4]], [[File:Orca-mathml-example-5.wav|thumb|Orca-mathml-example-5]], [[File:Orca-mathml-example-6.wav|thumb|Orca-mathml-example-6]], [[File:Orca-mathml-example-7.wav|thumb|Orca-mathml-example-7]].
** From our testing, ChromeVox and JAWS are not able to read the formulas generated by the MathML mode.


==Structural studies==
==Test pages ==


As of late 2007, 5 [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|1I1Q}}, {{PDB link|1I7Q}}, {{PDB link|1I7S}}, {{PDB link|1QDL}}, and {{PDB link|2I6Y}}.
To test the '''MathML''', '''PNG''', and '''source''' rendering modes, please go to one of the following test pages:
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==Application==
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*[[Url2Image|Url2Image (private Wikis only)]]
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==Bug reporting==
 
If you find any bugs, please report them at [https://bugzilla.wikimedia.org/enter_bug.cgi?product=MediaWiki%20extensions&component=Math&version=master&short_desc=Math-preview%20rendering%20problem Bugzilla], or write an email to math_bugs (at) ckurs (dot) de .
==References==
{{reflist|1}}
* {{cite journal | author = Baker TI, Crawford IP | year = 1966 | title = Anthranilate synthetase. Partial purification and some kinetic studies on the enzyme from Escherichia coli | journal = J. Biol. Chem.  | volume = 241 | pages = 5577&ndash;84  | pmid = 5333199 | issue = 23 }}
* {{cite journal | author = Creighton TE and Yanofsky C | year = 1970 | title = Chorismate to tryptophan (Escherichia coli) - Anthranilate synthetase, PR transferase, PRA isomerase, InGP synthetase, tryptophan synthetase | journal = Methods Enzymol.  | volume = 17A | pages = 365&ndash;380 | doi=10.1016/0076-6879(71)17215-1}}
* {{cite journal | author = Kung CC, Huang WN, Huang YC, Yeh KC | year = 2006 | title = Proteomic survey of copper-binding proteins in Arabidopsis roots by immobilized metal affinity chromatography and mass spectrometry | journal = Proteomics. | volume = 6 | pages = 2746&ndash;58  | pmid = 16526091 | doi = 10.1002/pmic.200500108 | issue = 9 }}
* {{cite journal | author = Ito J, Yanofsky C | year = 1969 | title = Anthranilate synthetase, an enzyme specified by the tryptophan operon of Escherichia coli: Comparative studies on the complex and the subunits | journal = J. Bacteriol.  | volume = 97 | pages = 734&ndash;42  | pmid = 4886290 | issue = 2 | pmc = 249753 }}
* {{cite journal | author = Zalkin H, Kling D | year = 1968 | title = Anthranilate synthetase. Purification and properties of component I from Salmonella typhimurium | journal = Biochemistry.  | volume = 7 | pages = 3566&ndash;73  | pmid = 4878701 | doi = 10.1021/bi00850a034 | issue = 10 }}
 
[[Category:EC 4.1.3]]
[[Category:Enzymes of known structure]]
[[Category:Anthranilates]]
 
 
{{4.1-enzyme-stub}}

Latest revision as of 23:52, 15 September 2019

This is a preview for the new MathML rendering mode (with SVG fallback), which is availble in production for registered users.

If you would like use the MathML rendering mode, you need a wikipedia user account that can be registered here [[1]]

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MathML


Follow this link to change your Math rendering settings. You can also add a Custom CSS to force the MathML/SVG rendering or select different font families. See these examples.

Demos

Here are some demos:


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