View source for 16S rRNA (cytosine1407-C5)-methyltransferase

{{Infobox enzyme
| Name = 23S rRNA (uracil<sup>1939</sup>-C<sup>5</sup>)-methyltransferase
| EC_number = 2.1.1.190
| CAS_number = 
| IUBMB_EC_number = 2/1/1/190
| GO_code = 
| image = 
| width = 
| caption =
}}
'''23S rRNA (uracil<sup>1939</sup>-C<sup>5</sup>)-methyltransferase''' ({{EC number|2.1.1.190}}, ''RumA'', ''RNA uridine methyltransferase A'', ''YgcA'') is an [[enzyme]] with system name ''S-adenosyl-L-methionine:23S rRNA (uracil<sup>1939</sup>-C<sup>5</sup>)-methyltransferase''.<ref>{{cite journal | title = Characterization of the 23 S ribosomal RNA m<sup>5</sup>U<sup>1939</sup> methyltransferase from ''Escherichia coli'' |author = Agarwalla, S., Kealey, J.T., Santi, D.V. and Stroud, R.M. |journal = J. Biol. Chem. |year = 2002 |volume = 277 |pages = 8835–8840 |pmid = 11779873 |doi=10.1074/jbc.M111825200 |issue=11}}</ref><ref>{{cite journal | title = Crystal structure of RumA, an iron-sulfur cluster containing ''E. coli'' ribosomal RNA 5-methyluridine methyltransferase |author = Lee, T.T., Agarwalla, S. and Stroud, R.M. |journal = Structure |year = 2004 |volume = 12 |pages = 397–407 |pmid = 15016356 |doi=10.1016/j.str.2004.02.009 |issue=3}}</ref><ref>{{cite journal | title = Identifying the methyltransferases for m<sup>5</sup>U<sup>747</sup> and m<sup>5</sup>U<sup>1939</sup> in 23S rRNA using MALDI mass spectrometry |author = Madsen, C.T., Mengel-Jorgensen, J., Kirpekar, F. and Douthwaite, S. |journal = Nucleic Acids Res. |year = 2003 |volume = 31 |pages = 4738–4746 |pmid = 12907714 |doi=10.1093/nar/gkg657}}</ref><ref>{{cite journal | title = Mutagenesis of the modified bases, m<sup>5</sup>U<sup>1939</sup> and &Psi;<sup>2504</sup>, in ''Escherichia coli'' 23S rRNA |author = Persaud, C., Lu, Y., Vila-Sanjurjo, A., Campbell, J.L., Finley, J. and O'Connor, M. |journal = Biochem. Biophys. Res. Commun. |year = 2010 |volume = 392 |pages = 223–227 |pmid = 20067766 |doi=10.1016/j.bbrc.2010.01.021 |issue=2}}</ref><ref>{{cite journal | title = Redox reactions of the iron-sulfur cluster in a ribosomal RNA methyltransferase, RumA: optical and EPR studies |author = Agarwalla, S., Stroud, R.M. and Gaffney, B.J. |journal = J. Biol. Chem. |year = 2004 |volume = 279 |pages = 34123–34129 |pmid = 15181002 |doi=10.1074/jbc.M405702200 |issue=33}}</ref><ref>{{cite journal | title = A unique RNA Fold in the RumA-RNA-cofactor ternary complex contributes to substrate selectivity and enzymatic function |author = Lee, T.T., Agarwalla, S. and Stroud, R.M. |journal = Cell |year = 2005 |volume = 120 |pages = 599–611 |pmid = 15766524 |doi=10.1016/j.cell.2004.12.037 |issue=5}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: [[S-adenosyl-L-methionine]] + [[uracil]]<sup>1939</sup> in [[Ribosomal RNA|23S rRNA]] <math>\rightleftharpoons</math> [[S-adenosyl-L-homocysteine]] + [[5-methyluracil]]<sup>1939</sup> in 23S rRNA

The enzyme specifically methylates uracil<sup>1939</sup> at C<sup>5</sup> in 23S rRNA.

== References ==
{{reflist}}

== External links ==
* {{MeshName|23S+rRNA+(uracil1939-C5)-methyltransferase}}

[[Category:EC 2.1.1]]