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{{Infobox enzyme
| Name = (+)-epicubenol synthase
| EC_number = 4.2.3.64
| CAS_number = 
| IUBMB_EC_number = 4/2/3/64
| GO_code = 
| image = 
| width = 
| caption =
}}
'''(+)-epicubenol synthase''' ({{EC number|4.2.3.64}}, ''farnesyl pyrophosphate cyclase'') is an [[enzyme]] with system name ''(2E,6E)-farnesyl-diphosphate diphosphate-lyase ((+)-epicubenol-forming)''.<ref>{{cite journal | title = Epicubenol synthase and the enzymatic cyclization of farnesyl diphosphate |author = Cane, D.E., Tandon, M., and Prabhakaran, P.C. |journal = J. Am. Chem. Soc. |year = 1993 |volume = 115 |pages = 8103–8106 |pmid = }}</ref><ref>{{cite journal | title = Biosynthesis of (+)-epicubenol. |author = Cane, D.E. and Tandon, M. |journal = Tetrahedron Lett. |year = 1994 |volume = 35 |pages = 5355–5358 |pmid = }}</ref><ref>{{cite journal | title = Epicubenol synthase and the stereochemistry of the enzymatic cyclization of farnesyl and nerolidyl diphosphate |author = Cane, D.E. and Tandon, M. |journal = J. Am. Chem. Soc. |year = 1995 |volume = 117 |pages = 5602–5603 |pmid = }}</ref><ref>{{cite journal | title = Bioynthesis of (+)-cubenene and (+)-epicubenol by cell-free extracts of cultured cells of ''Heteroscyphus planus'' and cyclization of [<sup>2</sup>H]farnesyl diphosphates |author = Nabeta, K., Kigure, K., Fujita, M., Nagoya, T., Ishikawa, T., Okuyama, H. and Takasawa, T. |journal = J. Chem. Soc., Perkin Trans. 1 |year = 1995 |volume =  |pages = 1935–1939 |pmid = }}</ref><ref>{{cite journal | title = ''In vitro'' biosynthesis of cadinanes by cell-free extracts of cultured cells of ''Heteroscyphus planus'' |author = Nabeta, K., Fujita, M., Komuro, K., Katayama, K., and Takasawa, T. |journal = J. Chem. Soc., Perkin Trans. 1 |year = 1997 |volume =  |pages = 2065–2070 |pmid = }}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: (2E,6E)-farnesyl diphosphate + H<sub>2</sub>O <math>\rightleftharpoons</math> (+)-[[epicubenol]] + [[diphosphate]]

This enzyme requires Mg<sup>2+</sup>.

== References ==
{{reflist}}

== External links ==
* {{MeshName|(+)-epicubenol+synthase}}

[[Category:EC 4.2.3]]