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| {{enzyme
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| | Name = 2-hydroxy-3-oxopropionate reductase
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| | EC_number = 1.1.1.60
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| | CAS_number = 9028-68-6
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| | IUBMB_EC_number = 1/1/1/60
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| | GO_code = 0008679
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| }}
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| In [[enzymology]], a '''2-hydroxy-3-oxopropionate reductase''' ({{EC number|1.1.1.60}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]
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| :(R)-glycerate + NAD(P)+ <math>\rightleftharpoons</math> 2-hydroxy-3-oxopropanoate + NAD(P)H + H<sup>+</sup>
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| The 3 [[substrate (biochemistry)|substrates]] of this enzyme are [[(R)-glycerate]], [[nicotinamide adenine dinucleotide|NAD<sup>+</sup>]], and [[nicotinamide adenine dinucleotide phosphate|NADP<sup>+</sup>]], whereas its 4 [[product (chemistry)|products]] are [[2-hydroxy-3-oxopropanoate]], [[nicotinamide adenine dinucleotide|NADH]], [[nicotinamide adenine dinucleotide phosphate|NADPH]], and [[hydrogen ion|H<sup>+</sup>]].
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| This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on the CH-OH group of donor with NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor. The systematic name of this enzyme class is '''(R)-glycerate:NAD(P)<sup>+</sup> oxidoreductase'''. This enzyme is also called '''tartronate semialdehyde reductase'''. This enzyme participates in [[glyoxylate and dicarboxylate metabolism]].
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| ==Structural studies==
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| As of late 2007, only one [[tertiary structure|structure]] has been solved for this class of enzymes, with the [[Protein Data Bank|PDB]] accession code {{PDB link|1YB4}}.
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| ==References==
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| {{reflist|1}}
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| * {{cite journal | author = Gotto AM, Kornberg HL | date = 1961 | title = The metabolism of C<sub>2</sub> compounds in micro-organisms. 7. Preparation and properties of crystalline tartronic semialdehyde reductase | journal = Biochem. J. | volume = 81 | pages = 273–84 | pmid = 13900766 | pmc = 1243334 | issue = 2 }}
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| [[Category:EC 1.1.1]] | |
| [[Category:NADPH-dependent enzymes]]
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| [[Category:NADH-dependent enzymes]]
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| [[Category:Enzymes of known structure]]
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| {{1.1.1-enzyme-stub}}
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Latest revision as of 11:44, 26 May 2014
Hi there. My name is Sophia Meagher even though it is not the name on my birth certification. Invoicing is my occupation. To play domino is some thing I really enjoy doing. North Carolina is the place he enjoys most but now he is contemplating other choices.
My website :: psychic phone; www.sirudang.com,