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{{enzyme
| Name = 6-carboxyhexanoate-CoA ligase
| EC_number = 6.2.1.14
| CAS_number = 55467-50-0
| IUBMB_EC_number = 6/2/1/14
| GO_code = 0042410
| image =
| width =
| caption =
}}
In [[enzymology]], a '''6-carboxyhexanoate—CoA ligase''' ({{EC number|6.2.1.14}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]


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:ATP + 6-carboxyhexanoate + CoA <math>\rightleftharpoons</math> AMP + diphosphate + 6-carboxyhexanoyl-CoA
 
The 3 [[substrate (biochemistry)|substrates]] of this enzyme are [[adenosine triphosphate|ATP]], [[6-carboxyhexanoate]], and [[coenzyme A|CoA]], whereas its 3 [[product (chemistry)|products]] are [[adenosine monophosphate|AMP]], [[diphosphate]], and [[6-carboxyhexanoyl-CoA]].
 
This enzyme belongs to the family of [[ligase]]s, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is '''6-carboxyhexanoate:CoA ligase (AMP-forming)'''. Other names in common use include '''6-carboxyhexanoyl-CoA synthetase''', and '''pimelyl-CoA synthetase'''. This enzyme participates in [[biotin metabolism]].
 
==References==
{{reflist|1}}
* {{cite journal | author = Izumi Y, Morita H, Sato K, Tani Y, Ogata K | year = 1972 | title = Synthesis of biotin-vitamers from pimelic acid and coenzyme A by cell-free extracts of various bacteria | journal = Biochim. Biophys. Acta. | volume = 264 | pages = 210&ndash;3  | pmid = 4623286 | issue = 1 }}
* {{cite journal | author = Izumi Y, Morita H, Tani Y and Ogata K | year = 1974 | title = The pimelyl-CoA synthetase responsible for the first step in biotin biosynthesis by microorganisms | journal = Agric. Biol. Chem. | volume = 38 | pages = 2257&ndash;2262 }}
 
{{DEFAULTSORT:6-carboxyhexanoate-CoA ligase}}
[[Category:EC 6.2.1]]
[[Category:Enzymes of unknown structure]]
 
 
{{ligase-stub}}

Latest revision as of 03:10, 9 June 2013

Template:Enzyme In enzymology, a 6-carboxyhexanoate—CoA ligase (Air Transportation Experts Kull from Wingham, has many interests that include butterflies, property developers in singapore and digital photography. Is a travel freak and in recent past made buy a house in singapore journey to Paleochristian and Byzantine Monuments of Thessalonika.) is an enzyme that catalyzes the chemical reaction

ATP + 6-carboxyhexanoate + CoA AMP + diphosphate + 6-carboxyhexanoyl-CoA

The 3 substrates of this enzyme are ATP, 6-carboxyhexanoate, and CoA, whereas its 3 products are AMP, diphosphate, and 6-carboxyhexanoyl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is 6-carboxyhexanoate:CoA ligase (AMP-forming). Other names in common use include 6-carboxyhexanoyl-CoA synthetase, and pimelyl-CoA synthetase. This enzyme participates in biotin metabolism.

References

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Template:Ligase-stub