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| Name = arginine 2-monooxygenase
| EC_number = 1.13.12.1
| CAS_number = 9027-36-5
| IUBMB_EC_number = 1/13/12/1
| GO_code = 0047678
| image =
| width =
| caption =
}}
'''Arginine 2-monooxygenase''' ({{EC number|1.13.12.1}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]
 
:L-arginine + O<sub>2</sub> <math>\rightleftharpoons</math> 4-guanidinobutanamide + CO<sub>2</sub> + H<sub>2</sub>O
 
Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[L-arginine]] and [[oxygen]], whereas its 3 [[product (chemistry)|products]] are [[4-guanidinobutanamide]], [[carbon dioxide]], and [[water]].
 
This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on single donors with O<sub>2</sub> as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O with incorporation of one atom of oxygen (internal monooxygenases o internal mixed-function oxidases). The systematic name of this enzyme class is '''L-arginine:oxygen 2-oxidoreductase (decarboxylating)'''. Other names in common use include '''arginine monooxygenase''', '''arginine decarboxylase''', '''arginine oxygenase (decarboxylating)''', and '''arginine decarboxy-oxidase'''.  This enzyme participates in [[urea cycle and metabolism of amino groups]]. It has one [[cofactor (biochemistry)|cofactor]]: the flavin [[FAD]].
 
==References==
{{reflist|1}}
* {{cite journal | author = Olomucki A, Pho DB, Lebar R, Delcambe L, Thoai NV | date = 1968 | title = [Arginine oxygenase (decarboxylating). V. Purification and flavin nature] | journal = Biochim. Biophys. Acta. | volume = 151 | pages = 353&ndash;66  | pmid = 4295160 | issue = 2 }}
* {{cite journal | author = Thoai NV and Olomucki A | date = 1962 | title = Arginine decarboxy-oxydase. I. Caracteres et nature de l'enzyme | journal = Biochim. Biophys. Acta  | volume = 59 | pages = 533&ndash;544 | doi = 10.1016/0006-3002(62)90631-5 | issue = 3 }}
* {{cite journal | author = Thoai NV and Olomucki A | date = 1962 | title = Arginine decarboxy-oxydase. II. Oxydation de la canavanine et de l'homoarginine en beta-guanidopropionamide et en delta-guanidovaleramide | journal = Biochim. Biophys. Acta  | volume = 59 | pages = 545&ndash;552 }}
 
[[Category:EC 1.13.12]]
[[Category:Flavin enzymes]]
[[Category:Flavoprotein enzymes]]
[[Category:Enzymes of unknown structure]]

Revision as of 02:53, 2 March 2013

Template:Enzyme Arginine 2-monooxygenase (Air Transportation Experts Kull from Wingham, has many interests that include butterflies, property developers in singapore and digital photography. Is a travel freak and in recent past made buy a house in singapore journey to Paleochristian and Byzantine Monuments of Thessalonika.) is an enzyme that catalyzes the chemical reaction

L-arginine + O2 4-guanidinobutanamide + CO2 + H2O

Thus, the two substrates of this enzyme are L-arginine and oxygen, whereas its 3 products are 4-guanidinobutanamide, carbon dioxide, and water.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O2 as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O with incorporation of one atom of oxygen (internal monooxygenases o internal mixed-function oxidases). The systematic name of this enzyme class is L-arginine:oxygen 2-oxidoreductase (decarboxylating). Other names in common use include arginine monooxygenase, arginine decarboxylase, arginine oxygenase (decarboxylating), and arginine decarboxy-oxidase. This enzyme participates in urea cycle and metabolism of amino groups. It has one cofactor: the flavin FAD.

References

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