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{{enzyme
| Name = adenine deaminase
| EC_number = 3.5.4.2
| CAS_number = 9027-68-3
| IUBMB_EC_number = 3/5/4/2
| GO_code = 0000034
| image =
| width =
| caption =
}}
In [[enzymology]], an '''adenine deaminase''' ({{EC number|3.5.4.2}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]


:adenine + H<sub>2</sub>O <math>\rightleftharpoons</math> hypoxanthine + NH<sub>3</sub>


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Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[adenine]] and [[water|H<sub>2</sub>O]], whereas its two [[product (chemistry)|products]] are [[hypoxanthine]] and [[ammonia|NH<sub>3</sub>]].
 
This enzyme belongs to the family of [[hydrolase]]s, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is '''adenine aminohydrolase'''. Other names in common use include '''adenase''', '''adenine aminase''', and '''ADase'''. This enzyme participates in [[purine metabolism]].  
 
==Structural studies==
 
As of late 2007, only one [[tertiary structure|structure]] has been solved for this class of enzymes, with the [[Protein Data Bank|PDB]] accession code {{PDB link|2ICS}}.
 
==References==
{{reflist|1}}
* {{cite journal | author = Blauch M, Koch FC and Hane ME | date = 1939 | title = A study of xanthine oxidase of rat blood | journal = J. Biol. Chem| volume = 130 | pages = 471&ndash;486 }}
* {{cite journal | author = Heppel LA, Hurwitz J and Horecker BL | date = 1957 | title = Adenine deaminase of Azotobacter vinelandii | journal = J. Am. Chem. Soc. | volume = 79 | pages = 630&ndash;633 | doi = 10.1021/ja01560a033 | issue = 3 }}
 
{{hydrolase-stub}}
 
[[Category:EC 3.5.4]]
[[Category:Enzymes of known structure]]

Revision as of 18:40, 13 May 2013

Template:Enzyme In enzymology, an adenine deaminase (Air Transportation Experts Kull from Wingham, has many interests that include butterflies, property developers in singapore and digital photography. Is a travel freak and in recent past made buy a house in singapore journey to Paleochristian and Byzantine Monuments of Thessalonika.) is an enzyme that catalyzes the chemical reaction

adenine + H2O hypoxanthine + NH3

Thus, the two substrates of this enzyme are adenine and H2O, whereas its two products are hypoxanthine and NH3.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is adenine aminohydrolase. Other names in common use include adenase, adenine aminase, and ADase. This enzyme participates in purine metabolism.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code Template:PDB link.

References

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Template:Hydrolase-stub