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{{enzyme
| Name = phospholipid-translocating ATPase
| EC_number = 3.6.3.1
| CAS_number =
| IUBMB_EC_number = 3/6/3/1
| GO_code = 0004012
| image =
| width =
| caption =
}}
In [[enzymology]], a '''phospholipid-translocating ATPase''' ({{EC number|3.6.3.1}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]
 
:ATP + H<sub>2</sub>O + phospholipidin <math>\rightleftharpoons</math> ADP + phosphate + phospholipidout
 
The 3 [[substrate (biochemistry)|substrates]] of this enzyme are [[adenosine triphosphate|ATP]], [[water|H<sub>2</sub>O]], and [[phospholipid]], whereas its 3 [[product (chemistry)|products]] are [[adenosine diphosphate|ADP]], [[phosphate]], and [[phospholipid]].
 
This enzyme belongs to the family of [[hydrolase]]s, specifically those acting on acid anhydrides to catalyse transmembrane movement of substances. The systematic name of this enzyme class is '''ATP phosphohydrolase (phospholipid-flipping)'''. Other names in common use include '''Mg<sup>2+</sup>-ATPase''', '''flippase''', and '''aminophospholipid-transporting ATPase'''.
 
==References==
{{reflist|1}}
* {{cite journal | author = Morris MB, Auland ME, Xu YH, Roufogalis BD | year = 1993 | title = Characterization of the Mg(2+)-ATPase activity of the human erythrocyte membrane | journal = Biochem. Mol. Biol. Int. | volume = 31 | pages = 823&ndash;32  | pmid = 8136700 | issue = 5 }}
* {{cite journal | doi = 10.3109/09687689609160582 | author = Vermeulen WP, Briede JJ, Roelofsen B | year = 1996 | title = Manipulation of the phosphatidylethanolamine pool in the human red cell membrane affects its Mg2+-ATPase activity | journal = Mol. Membr. Biol. | volume = 13 | pages = 95&ndash;102  | pmid = 8839453 | issue = 2 }}
* {{cite journal | author = Suzuki H, Kamakura M, Morii M, Takeguchi N | year = 1997 | title = The phospholipid flippase activity of gastric vesicles | journal = J. Biol. Chem| volume = 272 | pages = 10429&ndash;34  | pmid = 9099684 | doi = 10.1074/jbc.272.16.10429 | issue = 16 }}
* {{cite journal | author = Auland ME, Roufogalis BD, Devaux PF, Zachowski A | year = 1994 | title = Reconstitution of ATP-dependent aminophospholipid translocation in proteoliposomes | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 91 | pages = 10938&ndash;42  | pmid = 7971987 | doi = 10.1073/pnas.91.23.10938 | issue = 23 | pmc = 45141 }}
 
[[Category:EC 3.6.3]]
[[Category:Enzymes of unknown structure]]
 
 
{{hydrolase-stub}}

Revision as of 18:04, 29 January 2014

Template:Enzyme In enzymology, a phospholipid-translocating ATPase (Air Transportation Experts Kull from Wingham, has many interests that include butterflies, property developers in singapore and digital photography. Is a travel freak and in recent past made buy a house in singapore journey to Paleochristian and Byzantine Monuments of Thessalonika.) is an enzyme that catalyzes the chemical reaction

ATP + H2O + phospholipidin ADP + phosphate + phospholipidout

The 3 substrates of this enzyme are ATP, H2O, and phospholipid, whereas its 3 products are ADP, phosphate, and phospholipid.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to catalyse transmembrane movement of substances. The systematic name of this enzyme class is ATP phosphohydrolase (phospholipid-flipping). Other names in common use include Mg2+-ATPase, flippase, and aminophospholipid-transporting ATPase.

References

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Template:Hydrolase-stub