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| == visual branding is not branding Air Max 1 Og == | | The '''volume of distribution''' (V<sub>D</sub>), also known as '''apparent volume of distribution''', is a [[pharmacology|pharmacological]], theoretical volume that the total amount of administered drug would have to occupy (if it were uniformly distributed), to provide the same concentration as it currently is in blood plasma. Therefore, if VD is greater, it shows that the drug is more diluted than it should be (in the blood plasma), meaning more of it is distributed in tissue (i.e. not in plasma). It is defined as the [[Distribution (pharmacology)|distribution]] of a [[medication]] between [[Blood plasma|plasma]] and the rest of the body after [[oral administration|oral]] or [[parenteral]] dosing. It is defined as the theoretical volume in which the total amount of drug would need to be uniformly distributed to produce the desired blood concentration of a drug.<ref>http://www.merckmanuals.com/professional/sec21/ch324/ch324d.html</ref><ref name="urlUntitled Document">{{cite web |url=http://cpharm.vetmed.vt.edu/VM8314/VM8314PharmaModeling.htm |title=vetmed.vt.edu |work= |accessdate=}}</ref> In rough terms, drugs with high lipid solubility (non-polar), low rates of ionization or low plasma binding capabilities have higher volumes of distribution than drugs which are more polar, more highly ionized or exhibit high plasma binding in the body's environment. |
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| | Volume of distribution may be increased by [[renal failure]] (due to fluid retention) and [[liver failure]] (due to altered body fluid and [[plasma protein binding]]). Conversely it may be decreased in dehydration. |
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| | The [[initial volume of distribution]] describes blood concentrations prior to attaining the apparent volume of distribution and uses the same formula. |
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| == a personal fitness trainer Nike Air Australia == | | :::::::<math>{V_{D}} = \frac{\mathrm{total \ amount \ of \ drug \ in \ the \ body}}{\mathrm{drug \ blood \ plasma \ concentration}}</math> |
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| | Therefore the dose required to give a certain plasma concentration can be determined if the V<sub>D</sub> for that drug is known. The V<sub>D</sub> is '''not''' a physiologic value; it is more a reflection of how a drug will distribute throughout the body depending on several physicochemical properties, e.g. solubility, charge, size, etc. |
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| | The units for Volume of Distribution are typically reported in (ml or liter)/kg body weight. The fact that V<sub>D</sub> is a ratio of a theoretical volume to a fixed unit of body weight explains why the V<sub>D</sub> for children is typically higher than that for adults, even though children are smaller and weigh less. As body composition changes with age, V<sub>D</sub> decreases. |
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| == MyBCTeam and FacetoFace Nike Air Force Shoes Ebay == | | :::::::<math>{V_{D}} = {V_{P}} + {V_{T}} \left(\frac{fu}{fu_{t}}\right)</math> |
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| | {{main|Table of volume of distribution for drugs}} |
| | If you administer a dose D of a drug intravenously in one go (IV-bolus), you would naturally expect it to have an immediate blood concentration <math>C_0</math> which directly corresponds to the amount of blood contained in the body <math>V_{blood}</math>. Mathematically this would be: |
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| | <math>C_0 = D/V_{blood}</math> |
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| | But this is generally not what happens. Instead you observe that the drug has distributed out into some other volume (read organs/tissue). So probably the first question you want to ask is: how much of the drug is no longer in the blood stream? |
| | The volume of distribution <math>V_D</math> quantifies just that by specifying how big a volume you would need in order to observe the blood concentration actually measured. |
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| | A practical example for a simple case (mono-compartmental) would be to administer D=8 mg/kg to a human. A human has a blood volume of around <math>V_{blood}=</math>0.08 l/kg |
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| | This gives a <math>C_0=</math>100 µg/ml if the drug stays in the blood stream only, and thus its volume of distribution is the same as <math>V_{blood}</math> that is <math>V_D=</math> 0.08 l/kg. If the drug distributes into all body water the volume of distribution would increase to approximately <math>V_D=</math>0.57 l/kg |
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| | <ref name=textbookofmedicalphysiology5thed>{{cite book |title=Textbook of Medical Physiology |last=Guyton |first=Arthur C. |year=1976|edition=5th|publisher=W.B. Saunders|location=Philadelphia|page= 424|isbn=0-7216-4393-0}}</ref> |
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| == Yesterday Michael Kors Bags Australia Store == | | If the drug readily diffuses into the body fat the volume of distribution may increase dramatically, an example is [[chloroquine]] which has a <math>V_D=</math>250-302 l/kg |
| | <ref>{{cite journal |author=Wetsteyn JC |title=The pharmacokinetics of three multiple dose regimens of chloroquine: implications for malaria chemoprophylaxis |journal=Br J Clinical Pharmacology |volume=39 |issue=6 |pages=696–9 |year=1995 |pmid=7654492 |
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| | | [[Warfarin]] || 8L || Reflects a high degree of plasma protein binding. |
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| | | [[Theophylline]], [[Ethanol]]|| 30L || Represents distribution in total body water. |
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The volume of distribution (VD), also known as apparent volume of distribution, is a pharmacological, theoretical volume that the total amount of administered drug would have to occupy (if it were uniformly distributed), to provide the same concentration as it currently is in blood plasma. Therefore, if VD is greater, it shows that the drug is more diluted than it should be (in the blood plasma), meaning more of it is distributed in tissue (i.e. not in plasma). It is defined as the distribution of a medication between plasma and the rest of the body after oral or parenteral dosing. It is defined as the theoretical volume in which the total amount of drug would need to be uniformly distributed to produce the desired blood concentration of a drug.[1][2] In rough terms, drugs with high lipid solubility (non-polar), low rates of ionization or low plasma binding capabilities have higher volumes of distribution than drugs which are more polar, more highly ionized or exhibit high plasma binding in the body's environment.
Volume of distribution may be increased by renal failure (due to fluid retention) and liver failure (due to altered body fluid and plasma protein binding). Conversely it may be decreased in dehydration.
The initial volume of distribution describes blood concentrations prior to attaining the apparent volume of distribution and uses the same formula.
Equations
The volume of distribution is given by the following equation:
Therefore the dose required to give a certain plasma concentration can be determined if the VD for that drug is known. The VD is not a physiologic value; it is more a reflection of how a drug will distribute throughout the body depending on several physicochemical properties, e.g. solubility, charge, size, etc.
The units for Volume of Distribution are typically reported in (ml or liter)/kg body weight. The fact that VD is a ratio of a theoretical volume to a fixed unit of body weight explains why the VD for children is typically higher than that for adults, even though children are smaller and weigh less. As body composition changes with age, VD decreases.
The VD may also be used to determine how readily a drug will displace into the body tissue compartments relative to the blood:
Where:
- VT = apparent tissue volume
- fu = fraction unbound in plasma
- fuT = fraction unbound in tissue
Examples
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If you administer a dose D of a drug intravenously in one go (IV-bolus), you would naturally expect it to have an immediate blood concentration which directly corresponds to the amount of blood contained in the body . Mathematically this would be:
But this is generally not what happens. Instead you observe that the drug has distributed out into some other volume (read organs/tissue). So probably the first question you want to ask is: how much of the drug is no longer in the blood stream?
The volume of distribution quantifies just that by specifying how big a volume you would need in order to observe the blood concentration actually measured.
A practical example for a simple case (mono-compartmental) would be to administer D=8 mg/kg to a human. A human has a blood volume of around 0.08 l/kg
.[3]
This gives a 100 µg/ml if the drug stays in the blood stream only, and thus its volume of distribution is the same as that is 0.08 l/kg. If the drug distributes into all body water the volume of distribution would increase to approximately 0.57 l/kg
[4]
If the drug readily diffuses into the body fat the volume of distribution may increase dramatically, an example is chloroquine which has a 250-302 l/kg
[5]
In the simple mono-compartmental case the volume of distribution is defined as: , where the in practice is an extrapolated concentration at time=0 from the first early plasma concentrations after an IV-bolus administration (generally taken around 5min - 30min after giving the drug).
Sample values and equations
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43 year old Petroleum Engineer Harry from Deep River, usually spends time with hobbies and interests like renting movies, property developers in singapore new condominium and vehicle racing. Constantly enjoys going to destinations like Camino Real de Tierra Adentro.
External links
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- ↑ 20 year-old Real Estate Agent Rusty from Saint-Paul, has hobbies and interests which includes monopoly, property developers in singapore and poker. Will soon undertake a contiki trip that may include going to the Lower Valley of the Omo.
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- ↑ One of the biggest reasons investing in a Singapore new launch is an effective things is as a result of it is doable to be lent massive quantities of money at very low interest rates that you should utilize to purchase it. Then, if property values continue to go up, then you'll get a really high return on funding (ROI). Simply make sure you purchase one of the higher properties, reminiscent of the ones at Fernvale the Riverbank or any Singapore landed property Get Earnings by means of Renting
In its statement, the singapore property listing - website link, government claimed that the majority citizens buying their first residence won't be hurt by the new measures. Some concessions can even be prolonged to chose teams of consumers, similar to married couples with a minimum of one Singaporean partner who are purchasing their second property so long as they intend to promote their first residential property. Lower the LTV limit on housing loans granted by monetary establishments regulated by MAS from 70% to 60% for property purchasers who are individuals with a number of outstanding housing loans on the time of the brand new housing purchase. Singapore Property Measures - 30 August 2010 The most popular seek for the number of bedrooms in Singapore is 4, followed by 2 and three. Lush Acres EC @ Sengkang
Discover out more about real estate funding in the area, together with info on international funding incentives and property possession. Many Singaporeans have been investing in property across the causeway in recent years, attracted by comparatively low prices. However, those who need to exit their investments quickly are likely to face significant challenges when trying to sell their property – and could finally be stuck with a property they can't sell. Career improvement programmes, in-house valuation, auctions and administrative help, venture advertising and marketing, skilled talks and traisning are continuously planned for the sales associates to help them obtain better outcomes for his or her shoppers while at Knight Frank Singapore. No change Present Rules
Extending the tax exemption would help. The exemption, which may be as a lot as $2 million per family, covers individuals who negotiate a principal reduction on their existing mortgage, sell their house short (i.e., for lower than the excellent loans), or take part in a foreclosure course of. An extension of theexemption would seem like a common-sense means to assist stabilize the housing market, but the political turmoil around the fiscal-cliff negotiations means widespread sense could not win out. Home Minority Chief Nancy Pelosi (D-Calif.) believes that the mortgage relief provision will be on the table during the grand-cut price talks, in response to communications director Nadeam Elshami. Buying or promoting of blue mild bulbs is unlawful.
A vendor's stamp duty has been launched on industrial property for the primary time, at rates ranging from 5 per cent to 15 per cent. The Authorities might be trying to reassure the market that they aren't in opposition to foreigners and PRs investing in Singapore's property market. They imposed these measures because of extenuating components available in the market." The sale of new dual-key EC models will even be restricted to multi-generational households only. The models have two separate entrances, permitting grandparents, for example, to dwell separately. The vendor's stamp obligation takes effect right this moment and applies to industrial property and plots which might be offered inside three years of the date of buy. JLL named Best Performing Property Brand for second year running
The data offered is for normal info purposes only and isn't supposed to be personalised investment or monetary advice. Motley Fool Singapore contributor Stanley Lim would not personal shares in any corporations talked about. Singapore private home costs increased by 1.eight% within the fourth quarter of 2012, up from 0.6% within the earlier quarter. Resale prices of government-built HDB residences which are usually bought by Singaporeans, elevated by 2.5%, quarter on quarter, the quickest acquire in five quarters. And industrial property, prices are actually double the levels of three years ago. No withholding tax in the event you sell your property. All your local information regarding vital HDB policies, condominium launches, land growth, commercial property and more
There are various methods to go about discovering the precise property. Some local newspapers (together with the Straits Instances ) have categorised property sections and many local property brokers have websites. Now there are some specifics to consider when buying a 'new launch' rental. Intended use of the unit Every sale begins with 10 p.c low cost for finish of season sale; changes to 20 % discount storewide; follows by additional reduction of fiftyand ends with last discount of 70 % or extra. Typically there is even a warehouse sale or transferring out sale with huge mark-down of costs for stock clearance. Deborah Regulation from Expat Realtor shares her property market update, plus prime rental residences and houses at the moment available to lease Esparina EC @ Sengkang