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| {{enzyme
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| | Name = alanine-tRNA ligase
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| | EC_number = 6.1.1.7
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| | CAS_number = 9031-71-4
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| | IUBMB_EC_number = 6/1/1/7
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| | GO_code = 0004813
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| }}
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| In [[enzymology]], an '''alanine-tRNA ligase''' ({{EC number|6.1.1.7}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]
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| :ATP + L-alanine + tRNAAla <math>\rightleftharpoons</math> AMP + diphosphate + L-alanyl-tRNAAla
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| The 3 [[substrate (biochemistry)|substrates]] of this enzyme are [[adenosine triphosphate|ATP]], [[L-alanine]], and [[tRNA(Ala)]], whereas its 3 [[product (chemistry)|products]] are [[adenosine monophosphate|AMP]], [[diphosphate]], and [[L-alanyl-tRNA(Ala)]].
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| This enzyme belongs to the family of [[ligase]]s, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is '''L-alanine:tRNAAla ligase (AMP-forming)'''. Other names in common use include '''alanyl-tRNA synthetase''', '''alanyl-transfer ribonucleate synthetase''', '''alanyl-transfer RNA synthetase''', '''alanyl-transfer ribonucleic acid synthetase''', '''alanine-transfer RNA ligase''', '''alanine transfer RNA synthetase''', '''alanine tRNA synthetase''', '''alanine translase''', '''alanyl-transfer ribonucleate synthase''', '''AlaRS''', and '''Ala-tRNA synthetase'''. This enzyme participates in [[alanine and aspartate metabolism]] and [[aminoacyl-trna biosynthesis]].
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| ==See also==
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| *[[Sticky mouse]] - mutation in the gene
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| ==Structural studies==
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| As of late 2007, 7 [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|1RIQ}}, {{PDB link|1V4P}}, {{PDB link|1YFR}}, {{PDB link|1YFS}}, {{PDB link|1YFT}}, {{PDB link|1YGB}}, and {{PDB link|2E1B}}.
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| ==References==
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| {{reflist|1}}
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| * {{cite journal | author = HOLLEY RW, GOLDSTEIN J | year = 1959 | title = An alanine-dependent, ribonuclease-inhibited conversion of adenosine 5'-phosphate to adenosine triphosphate. II. Reconstruction of the system from purified components | journal = J. Biol. Chem. | volume = 234 | pages = 1765–8 | pmid = 13672960 | issue = 7 }}
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| * {{cite journal | author = Webster GC | year = 1961 | title = Isolation of an alanine-activating enzyme from pig liver | journal = Biochim. Biophys. Acta | volume = 49 | pages = 141–152 | doi = 10.1016/0006-3002(61)90877-0 | pmid = 13783653 }}
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| {{Ligases}}
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| {{DEFAULTSORT:Alanine-tRNA ligase}}
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| [[Category:EC 6.1.1]]
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| [[Category:Enzymes of known structure]]
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| {{ligase-stub}}
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