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| {{enzyme
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| | Name = vitamin-K-epoxide reductase (warfarin-sensitive)
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| | EC_number = 1.1.4.1
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| | CAS_number = 55963-40-1
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| | IUBMB_EC_number = 1/1/4/1
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| | GO_code = 0047057
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| }}
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| In [[enzymology]], a '''vitamin-K-epoxide reductase (warfarin-sensitive)''' ({{EC number|1.1.4.1}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]
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| :2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol <math>\rightleftharpoons</math> 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol
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| Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[2-methyl-3-phytyl-1,4-naphthoquinone]] and [[oxidized dithiothreitol]], whereas its two [[product (chemistry)|products]] are [[2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone]] and [[1,4-dithiothreitol]].
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| This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on the CH-OH group of donor with a disulfide as acceptor. The systematic name of this enzyme class is '''2-methyl-3-phytyl-1,4-naphthoquinone:oxidized-dithiothreitol oxidoreductase'''. This enzyme participates in [[biosynthesis of steroids]]. At least one compound, [[Warfarin]] is known to [[enzyme inhibitor|inhibit this enzyme]].
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| == References ==
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| {{reflist|1}}
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| * {{cite journal | author = Lee JJ, Fasco MJ | date = 1984 | title = Metabolism of vitamin K and vitamin K 2,3-epoxide via interaction with a common disulfide | journal = Biochemistry. | volume = 23 | pages = 2246–52 | pmid = 6733086 | doi = 10.1021/bi00305a024 | issue = 10 }}
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| * {{cite journal | author = Mukharji I, Silverman RB | date = 1985 | title = Purification of a vitamin K epoxide reductase that catalyzes conversion of vitamin K 2,3-epoxide to 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 82 | pages = 2713–7 | pmid = 3857611 | doi = 10.1073/pnas.82.9.2713 | issue = 9 | pmc = 397635 }}
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| * {{cite journal | author = Whitlon DS, Sadowski JA, Suttie JW | date = 1978 | title = Mechanism of coumarin action: significance of vitamin K epoxide reductase inhibition | journal = Biochemistry. | volume = 17 | pages = 1371–7 | pmid = 646989 | doi = 10.1021/bi00601a003 | issue = 8 }}
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| {{1.1-enzyme-stub}}
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| [[Category:EC 1.1.4]]
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| [[Category:Enzymes of unknown structure]]
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