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| Name = ADP-specific glucokinase
| EC_number = 2.7.1.147
| CAS_number = 173585-07-4
| IUBMB_EC_number = 2/7/1/147
| GO_code = 0043843
| image =
| width =
| caption =
}}
{{PBB|geneid=83440}}
In [[enzymology]], an '''ADP-specific glucokinase''' ({{EC number|2.7.1.147}}) also known as  '''ADP-dependent glucokinase''' is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]
 
:ADP + D-glucose <math>\rightleftharpoons</math> AMP + D-glucose 6-phosphate
 
Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[adenosine diphosphate|ADP]] and [[D-glucose]], whereas its two [[product (chemistry)|products]] are [[adenosine monophosphate|AMP]] and [[D-glucose 6-phosphate]].
 
This enzyme belongs to the family of [[transferase]]s, to be specific those transferring phosphorus-containing groups ([[phosphotransferase]]s) with an alcohol group as acceptor.
 
In humans, the ADP-dependent glucokinase is encoded by the ''ADPGK'' [[gene]].<ref name="pmid14975750">{{cite journal | author = Ronimus RS, Morgan HW | title = Cloning and biochemical characterization of a novel mouse ADP-dependent glucokinase | journal = Biochem. Biophys. Res. Commun. | volume = 315 | issue = 3 | pages = 652–8 |date=March 2004 | pmid = 14975750 | doi = 10.1016/j.bbrc.2004.01.103 | url =  }}</ref>
 
==Structural studies==
 
As of late 2007, only one [[tertiary structure|structure]] has been solved for this class of enzymes, with the [[Protein Data Bank|PDB]] accession code {{PDB link|1GC5}}.
 
==References==
{{reflist}}
 
==Further reading==
{{refbegin | 2}}
* {{cite journal | author = Kengen SW, Tuininga JE, de Bok FA, Stams AJ, de Vos WM | year = 1995 | title = Purification and characterization of a novel ADP-dependent glucokinase from the hyperthermophilic archaeon Pyrococcus furiosus | journal = J. Biol. Chem.  | volume = 270 | pages = 30453&ndash;7  | pmid = 8530474 | doi = 10.1074/jbc.270.51.30453 | issue = 51 }}
*{{cite journal  |author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  |pmc=528928  |author-separator=, |author2=Wagner L  |author3=Feingold EA  |display-authors=3  |last4=Shenmen  |first4=CM  |last5=Grouse  |first5=LH  |last6=Schuler  |first6=G  |last7=Klein  |first7=SL  |last8=Old  |first8=S  |last9=Rasooly  |first9=R }}
*{{cite journal  |author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285  |author-separator=, |author2=Suzuki Y  |author3=Nishikawa T  |display-authors=3  |last4=Otsuki  |first4=Tetsuji  |last5=Sugiyama  |first5=Tomoyasu  |last6=Irie  |first6=Ryotaro  |last7=Wakamatsu  |first7=Ai  |last8=Hayashi  |first8=Koji  |last9=Sato  |first9=Hiroyuki }}
*{{cite journal  |author=Otsuki T |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries |journal=DNA Res. |volume=12 |issue= 2 |pages= 117–26 |year= 2005 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117  |author-separator=,  |author2=Ota T  |author3=Nishikawa T  |display-authors=3  |last4=Hayashi  |first4=K  |last5=Suzuki  |first5=Y  |last6=Yamamoto  |first6=J  |last7=Wakamatsu  |first7=A  |last8=Kimura  |first8=K  |last9=Sakamoto  |first9=K }}
*{{cite journal  |author=Kimura K |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406  |pmc=1356129  |author-separator=, |author2=Wakamatsu A  |author3=Suzuki Y  |display-authors=3  |last4=Ota  |first4=T  |last5=Nishikawa  |first5=T  |last6=Yamashita  |first6=R  |last7=Yamamoto  |first7=J  |last8=Sekine  |first8=M  |last9=Tsuritani  |first9=K }}
*{{cite journal  |author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |doi= 10.1073/pnas.242603899  |pmc=139241  |author-separator=,  |author2=Feingold EA  |author3=Grouse LH  |display-authors=3 |last4=Derge  |first4=JG  |last5=Klausner  |first5=RD  |last6=Collins  |first6=FS  |last7=Wagner  |first7=L  |last8=Shenmen  |first8=CM  |last9=Schuler  |first9=GD }}
*{{cite journal  |author=Ronimus RS, Morgan HW |title=Cloning and biochemical characterization of a novel mouse ADP-dependent glucokinase |journal=Biochem. Biophys. Res. Commun. |volume=315 |issue= 3 |pages= 652–8 |year= 2004 |pmid= 14975750 |doi= 10.1016/j.bbrc.2004.01.103 }}
*{{cite journal |author=Wiemann S |title=Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R  |pmc=311072  |author-separator=,  |author2=Weil B  |author3=Wellenreuther R  |display-authors=3  |last4=Gassenhuber  |first4=J  |last5=Glassl  |first5=S  |last6=Ansorge  |first6=W  |last7=Böcher  |first7=M  |last8=Blöcker  |first8=H  |last9=Bauersachs  |first9=S }}
*{{cite journal  |author=Lim J |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032  |author-separator=,  |author2=Hao T  |author3=Shaw C  |display-authors=3  |last4=Patel  |first4=Akash J.  |last5=Szabó  |first5=Gábor  |last6=Rual  |first6=Jean-François  |last7=Fisk  |first7=C. Joseph  |last8=Li  |first8=Ning  |last9=Smolyar  |first9=Alex }}
{{refend}}
 
{{enzyme-stub}}
 
[[Category:EC 2.7.1]]
[[Category:Enzymes of known structure]]

Latest revision as of 10:04, 6 January 2015

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