Acetylornithine deacetylase: Difference between revisions

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{{enzyme
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| Name = agmatinase
| EC_number = 3.5.3.11
| CAS_number = 37289-16-0
| IUBMB_EC_number = 3/5/3/11
| GO_code = 0008783
| image =
| width =
| caption =
}}
In [[enzymology]], an '''agmatinase''' ({{EC number|3.5.3.11}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]
 
:agmatine + H<sub>2</sub>O <math>\rightleftharpoons</math> putrescine + urea
 
Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[agmatine]] and [[water|H<sub>2</sub>O]], whereas its two [[product (chemistry)|products]] are [[putrescine]] and [[urea]].
 
This enzyme belongs to the family of [[hydrolase]]s, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amidines.  The systematic name of this enzyme class is '''agmatine amidinohydrolase'''. Other names in common use include '''agmatine ureohydrolase''', and '''SpeB'''.  This enzyme participates in [[urea cycle and metabolism of amino groups]].
 
==Genetics==
{{PBB|geneid=79814}}
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->{{PBB_Summary
| section_title =
| summary_text =
}}In humans, the enzyme is encoded by the ''AGMAT'' [[gene]].<ref name="pmid11804860">{{cite journal | author = Mistry SK, Burwell TJ, Chambers RM, Rudolph-Owen L, Spaltmann F, Cook WJ, Morris SM Jr | title = Cloning of human agmatinase. An alternate path for polyamine synthesis induced in liver by hepatitis B virus | journal = Am J Physiol Gastrointest Liver Physiol | volume = 282 | issue = 2 | pages = G375–81 |date=Jan 2002 | pmid = 11804860 | pmc =  | doi = 10.1152/ajpgi.00386.2001 }}</ref><ref name="pmid14648699">{{cite journal | author = Dallmann K, Junker H, Balabanov S, Zimmermann U, Giebel J, Walther R | title = Human agmatinase is diminished in the clear cell type of renal cell carcinoma | journal = Int J Cancer | volume = 108 | issue = 3 | pages = 342–7 |date=Dec 2003 | pmid = 14648699 | pmc =  | doi = 10.1002/ijc.11459 }}</ref><ref name="pmid11914032">{{cite journal | author = Iyer RK, Kim HK, Tsoa RW, Grody WW, Cederbaum SD | title = Cloning and characterization of human agmatinase | journal = Mol Genet Metab | volume = 75 | issue = 3 | pages = 209–18 |date=Mar 2002 | pmid = 11914032 | pmc =  | doi = 10.1006/mgme.2001.3277 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: AGMAT agmatine ureohydrolase (agmatinase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79814| accessdate = }}</ref>
 
==Structural studies==
 
As of late 2007, 5 [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|1GQ6}}, {{PDB link|1GQ7}}, {{PDB link|1WOG}}, {{PDB link|1WOH}}, and {{PDB link|1WOI}}.
 
==Inhibitors==
* [[Piperazine-1-carboxamidine]]
 
==References==
{{reflist|1}}
*{{cite journal  | author=Morris SM |title=Vertebrate agmatinases: what role do they play in agmatine catabolism? |journal=Ann. N. Y. Acad. Sci. |volume=1009 |issue=  |pages= 30–3 |year= 2004 |pmid= 15028567 |doi=10.1196/annals.1304.003  }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8  }}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3  }}
*{{cite journal  | author=Chen FW, Davies JP, Ioannou YA |title=Differential gene expression in apoptosis: identification of ribosomal protein 23K, a cell proliferation inhibitor |journal=Mol. Genet. Metab. |volume=64 |issue= 4 |pages= 271–82 |year= 1998 |pmid= 9758718 |doi= 10.1006/mgme.1998.2718 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal  | author=Kim KH, Ahn HJ, Kim DJ, ''et al.'' |title=Expression, crystallization and preliminary X-ray crystallographic analysis of human agmatinase |journal=Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. |volume=61 |issue= Pt 10 |pages= 889–91 |year= 2006 |pmid= 16511187 |doi= 10.1107/S1744309105027193  | pmc=1991308 }}
*{{cite journal  | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1 |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
* {{cite journal | author = Hirshfield IN, Rosenfeld HJ, Leifer Z, Maas WK | date = 1970 | title = Isolation and Characterization of a Mutant of Escherichia coli Blocked in the Synthesis of Putrescine | journal = J. Bacteriol.  | volume = 101 | pages = 725&ndash;30  | pmid = 4908780 | issue = 3 | pmc = 250384 }}
* {{cite journal | author = Vicente C and Legaz ME | date = 1982 | title = Preparation and properties of agmatine amidinohydrolase of Evernia prunastri | journal = Physiol. Plant.  | volume = 55 | pages = 335&ndash;339 }}
* {{MeshName|agmatinase}}
 
{{Carbon-nitrogen non-peptide hydrolases}}
{{Amino acid metabolism enzymes}}
 
[[Category:EC 3.5.3]]
[[Category:Enzymes of known structure]]
 
{{hydrolase-stub}}

Latest revision as of 10:18, 16 December 2014

Your world wide web dating good results relies mostly on the strength of your profile. A nicely-written, very carefully planned profile can get you lots of responses, exactly where a dashed-off, careless 1 won"t. Several folks who have difficulty dating on the internet can trace their troubles back to a poor profile.

You never have to be a prize-winning author to produce a ...

If you take the time to believe about what"s going into your profile, you"ll create anything that other individuals will want to read.

Your web dating good results relies mainly on the strength of your profile. A properly-written, carefully planned profile can get you lots of responses, where a dashed-off, careless one particular won"t. Numerous individuals who have trouble dating online can trace their issues back to a poor profile.

You don"t have to be a prize-winning author to generate a very good profile. Just following some basic guidelines can get your profile moving in the correct course:

Add a excellent headline

Most net daters browse through profiles, seeking for some thing that catches their eye. That is why you need to have to come up with a very good headline for your profile. Decide on one thing humorous, or possibly pose a query. Keep it tasteful, to avoid finding undesirable responses and hold it brief and snappy so that browsers can read it all without having obtaining to go into your profile.

Be your self

The majority of on the web daters are looking for a person with whom they can have a severe relationship. Browse here at the link tumbshots to research the purpose of it. There"s no point in pretending to be a person you are not, since it will backfire ultimately. As an alternative, be brave and be yourself. Honesty is an attractive quality and there"s a person out there who"s searching for somebody just like you.

Come up with a strategy

Ahead of you create you profile, make a list of all the items you want to say. Bear in mind that you want to let people know what you are looking for, what you are like, your interests and hobbies, your age and something else that you think will encourage individuals to get in touch. Create a couple of draft profiles and read them by means of or get a person else to read them so that you can be sure that what you have written makes sense. Get more on an affiliated site - Click here: its just lunch washington dc content. Be taught further on this partner essay - Visit this website: its just lunch washington dc news. Only post your profile once you are positive it says anything you want it to..

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