6-oxocineole dehydrogenase: Difference between revisions

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{{enzyme
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| Name = alkane 1-monooxygenase
| EC_number = 1.14.15.3
| CAS_number = 9059-16-9
| IUBMB_EC_number = 1/14/15/3
| GO_code = 0018685
| image =
| width =
| caption =
}}
In [[enzymology]], an '''alkane 1-monooxygenase''' ({{EC number|1.14.15.3}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reactions]]
 
:an alkane + reduced rubredoxin + O<sub>2</sub> <math>\rightleftharpoons</math> a primary alcohol + oxidized rubredoxin + H<sub>2</sub>O.
 
Alkanes of 6 to 22 carbons have been observed as substrates.<ref>{{cite journal | author = McKenna EJ, Coon MJ | year = 1970 | title = Enzymatic omega-oxidation. IV. Purification and properties of the omega-hydroxylase of Pseudomonas oleovorans | journal = J. Biol. Chem.  | volume = 245 | pages = 3882&ndash;9  | pmid = 4395379 | issue = 15 }}</ref> This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on paired donors, with oxygen as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O<sub>2</sub> with reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor.  The systematic name of this enzyme class is '''alkane, reduced-rubredoxin:oxygen 1-oxidoreductase'''. Other names in common use include '''alkane 1-hydroxylase''', '''omega-hydroxylase''', '''fatty acid omega-hydroxylase''', '''alkane monooxygenase''', '''1-hydroxylase''', AlkB, and '''alkane hydroxylase'''.   It contains a diiron non-heme active site.  
 
==References==
{{reflist|1}}
* {{cite journal | author = Cardini G, Jurtshuk P | year = 1970 | title = The enzymatic hydroxylation of n-octane by Corynebacterium sp strain 7E1C | journal = J. Biol. Chem.  | volume = 245 | pages = 2789&ndash;96  | pmid = 4317878 | issue = 11 }}
* {{cite journal | author = Peterson JA, Kusunose M, Kusunose E, Coon MJ | year = 1967 | title = Enzymatic omega-oxidation. II. Function of rubredoxin as the electron carrier in omega-hydroxylation | journal = J. Biol. Chem.  | volume = 242 | pages = 4334&ndash;40  | pmid = 4294330 | issue = 19 }}
 
[[Category:EC 1.14.15]]
[[Category:Heme enzymes]]
[[Category:Enzymes of unknown structure]]
 
 
{{1.14-enzyme-stub}}

Latest revision as of 12:14, 26 May 2014

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