Abequosyltransferase: Difference between revisions

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{{enzyme
| Name = alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase
| EC_number = 2.4.99.3
| CAS_number = 71124-50-0
| IUBMB_EC_number = 2/4/99/3
| GO_code = 0001665
| image =
| width =
| caption =
}}
In [[enzymology]], an '''alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase''' ({{EC number|2.4.99.3}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]


:CMP-N-acetylneuraminate + glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein <math>\rightleftharpoons</math> CMP + glycano-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)- glycoprotein


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Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[CMP-N-acetylneuraminate]] and [[glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein]], whereas its 3 [[product (chemistry)|products]] are [[cytidine monophosphate|CMP]], [[glycano-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-]], and [[glycoprotein]].
 
This enzyme belongs to the family of [[transferase]]s, specifically those [[glycosyltransferase]]s that do not transfer hexosyl or pentosyl groups. The systematic name of this enzyme class is '''CMP-N-acetylneuraminate:glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein alpha-2,6-N-acetylneuraminyltransferase'''. This enzyme participates in [[o-glycan biosynthesis]] and [[glycan structures - biosynthesis 1]].
 
==References==
{{reflist|1}}
*{{cite journal | author = Sadler JE, Rearick JI, Hill RL | year = 1979 | title = Purification to homogeneity and enzymatic characterization of an alpha-N-acetylgalactosaminide alpha 2 leads to 6 sialyltransferase from porcine submaxillary glands | journal = J. Biol. Chem. | volume = 254 | pages = 5934–41  | pmid = 447688 | issue = 13 }}
 
[[Category:EC 2.4.99]]
[[Category:Enzymes of unknown structure]]
 
 
{{enzyme-stub}}

Latest revision as of 22:26, 17 March 2013

Template:Enzyme In enzymology, an alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase (Air Transportation Experts Kull from Wingham, has many interests that include butterflies, property developers in singapore and digital photography. Is a travel freak and in recent past made buy a house in singapore journey to Paleochristian and Byzantine Monuments of Thessalonika.) is an enzyme that catalyzes the chemical reaction

CMP-N-acetylneuraminate + glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein CMP + glycano-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)- glycoprotein

Thus, the two substrates of this enzyme are CMP-N-acetylneuraminate and glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein, whereas its 3 products are CMP, glycano-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-, and glycoprotein.

This enzyme belongs to the family of transferases, specifically those glycosyltransferases that do not transfer hexosyl or pentosyl groups. The systematic name of this enzyme class is CMP-N-acetylneuraminate:glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein alpha-2,6-N-acetylneuraminyltransferase. This enzyme participates in o-glycan biosynthesis and glycan structures - biosynthesis 1.

References

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