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{{enzyme
| Name = 4-hydroxybutyrate dehydrogenase
| EC_number = 1.1.1.61
| CAS_number =
| IUBMB_EC_number = 1/1/1/61
| GO_code = 0047577
| image =
| width =
| caption =
}}
In [[enzymology]], a '''4-hydroxybutyrate dehydrogenase''' ({{EC number|1.1.1.61}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:4-hydroxybutanoate + NAD+ <math>\rightleftharpoons</math> succinate semialdehyde + NADH + H+

The two [[substrate (biochemistry)|substrates]] of this enzyme are therefore 4-hydroxybutanoic acid, and [[nicotinamide adenine dinucleotide|NAD+]], whereas its 3 [[product (chemistry)|products]] are [[succinate semialdehyde]], [[nicotinamide adenine dinucleotide|NADH]], and [[hydrogen ion|H+]].

This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor.<ref>{{cite journal | author = Nirenberg MW and Jakoby WB | year = 1960 | title = Enzymatic utilization of gamma-hydroxybutyric acid | journal = J. Biol. Chem. | volume = 235 | pages = 954–960 | pmid=14427301}}</ref> The systematic name of this enzyme class is '''4-hydroxybutanoate:NAD+ oxidoreductase'''. This enzyme is also called '''gamma-hydroxybutyrate dehydrogenase'''. This enzyme participates in [[butanoate metabolism]] and the degradation of the [[neurotransmitter]] [[gamma-Hydroxybutyric acid|4-hydroxybutanoic acid]].<ref>{{cite journal |author=Kaufman EE, Nelson T |title=An overview of gamma-hydroxybutyrate catabolism: the role of the cytosolic NADP+-dependent oxidoreductase EC 1.1.1.19 and of a mitochondrial hydroxyacid-oxoacid transhydrogenase in the initial, rate-limiting step in this pathway |journal=Neurochem. Res. |volume=16 |issue=9 |pages=965–974 |year=1991 |pmid=1784339 |doi=10.1007/BF00965839}}</ref>

==References==
{{reflist|1}}

[[Category:EC 1.1.1]]
[[Category:NADH-dependent enzymes]]
[[Category:Enzymes of unknown structure]]

{{1.1.1-enzyme-stub}}

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