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{{enzyme
| Name = trans-octaprenyltranstransferase
| EC_number = 2.5.1.11
| CAS_number = 64763-52-6
| IUBMB_EC_number = 2/5/1/11
| GO_code = 0050347
| image = 
| width = 
| caption = 
}}
In [[enzymology]], a '''trans-octaprenyltranstransferase''' ({{EC number|2.5.1.11}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:all-trans-octaprenyl diphosphate + isopentenyl diphosphate <math>\rightleftharpoons</math> diphosphate + all-trans-nonaprenyl diphosphate

Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[all-trans-octaprenyl diphosphate]] and [[isopentenyl diphosphate]], whereas its two [[product (chemistry)|products]] are [[diphosphate]] and [[all-trans-nonaprenyl diphosphate]].

This enzyme belongs to the family of [[transferase]]s, specifically those transferring aryl or alkyl groups other than methyl groups.  The systematic name of this enzyme class is '''(E)-octaprenyl-diphosphate:isopentenyl-diphosphate octaprenyltranstransferase'''. Other names in common use include '''all-trans-nonaprenyl-diphosphate synthase''', '''solanesyl-diphosphate synthase''', '''solanesyl pyrophosphate synthetase''', '''SPP synthase''', '''nonaprenyl pyrophosphate synthetase''', '''polyprenylpyrophosphate synthetase''', '''terpenoidallyltransferase''', '''terpenyl pyrophosphate synthetase''', '''trans-octaprenyltranstransferase''', and '''trans-prenyltransferase'''.  This enzyme participates in [[biosynthesis of steroids]].  

==Structural studies==

As of late 2007, 16 [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|1V4E}}, {{PDB link|1V4H}}, {{PDB link|1V4I}}, {{PDB link|1V4J}}, {{PDB link|1V4K}}, {{PDB link|1VG2}}, {{PDB link|1VG3}}, {{PDB link|1VG4}}, {{PDB link|1VG6}}, {{PDB link|1VG7}}, {{PDB link|1WKZ}}, {{PDB link|1WL0}}, {{PDB link|1WL1}}, {{PDB link|1WL2}}, {{PDB link|1WL3}}, and {{PDB link|2AZL}}.

==References==
{{reflist|1}}
* {{cite journal | author = Fujii H, Sagami H, Koyama T, Ogura K, Seto S, Baba T, Allen CM | date = 1980 | title = Variable product specificity of solanesyl pyrophosphate synthetase | journal = Biochem. Biophys. Res. Commun.  | volume = 96 | pages = 1648&ndash;53  | pmid = 7447947 | doi = 10.1016/0006-291X(80)91363-7 | issue = 4 }}
* {{cite journal | author = Sagami H, Ogura K and Seto S | date = 1978 | title = Solanesyl pyrophosphate synthetase from Micrococcus lysodeikticus | journal = Biochemistry  | volume = 16 | pages = 4616&ndash;4622 | doi = 10.1021/bi00640a014 | pmid=911777 | issue = 21}}

{{transferase-stub}}

[[Category:EC 2.5.1]]
[[Category:Enzymes of known structure]]