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{{Infobox enzyme
| Name = D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase
| EC_number = 2.7.7.70
| CAS_number = 
| IUBMB_EC_number = 2/7/7/70
| GO_code = 
| image = 
| width = 
| caption =
}}
'''D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase''' ({{EC number|2.7.7.70}}, ''D-beta-D-heptose 7-phosphate kinase/D-beta-D-heptose 1-phosphate adenylyltransferase'', ''D-glycero-D-manno-heptose-1beta-phosphate adenylyltransferase'', ''hldE (gene)'', ''rfaE (gene)'') is an [[enzyme]] with system name ''ATP:D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase''.<ref>{{cite journal | title = The <em>rfaE</em> gene from <em>Escherichia coli</em> encodes a bifunctional protein involved in biosynthesis of the lipopolysaccharide core precursor  ADP-<small>L</small>-<em>glycero</em>-<small>D</small>-<em>manno</em>-heptose |author = Valvano, M.A., Marolda, C.L., Bittner, M., Glaskin-Clay, M., Simon, T.L. and Klena, J.D. |journal = J. Bacteriol. |year = 2000 |volume = 182 |pages = 488–497 |pmid = 10629197}}</ref><ref>{{cite journal | title = Biosynthesis pathway of ADP-<small>L</small>-<em>glycero</em>-&beta;-<small>D</small>-<em>manno</em>-heptose in <em>Escherichia coli</em> |author = Kneidinger, B., Marolda, C., Graninger, M., Zamyatina, A., McArthur, F., Kosma, P., Valvano, M.A. and Messner, P. |journal = J. Bacteriol. |year = 2002 |volume = 184 |pages = 363–369 |pmid = 11751812}}</ref><ref>{{cite journal | title = Novel pathways for biosynthesis of nucleotide-activated <em>glycero</em>-<em>manno</em>-heptose precursors of bacterial glycoproteins and cell  surface polysaccharides |author = Valvano, M.A., Messner, P. and Kosma, P. |journal = Microbiology |year = 2002 |volume = 148 |pages = 1979–1989 |pmid = 12101286}}</ref><ref>{{cite journal | title = Divergence of biochemical function in the HAD superfamily: <small>D</small>-<em>glycero</em>-<small>D</small>-<em>manno</em>-heptose-1,7-bisphosphate phosphatase (GmhB) |author = Wang, L., Huang, H., Nguyen, H.H., Allen, K.N., Mariano, P.S. and Dunaway-Mariano, D. |journal = Biochemistry |year = 2010 |volume = 49 |pages = 1072–1081 |pmid = 20050615}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: D-glycero-beta-D-manno-heptose 1-phosphate + ATP <math>\rightleftharpoons</math> ADP-D-glycero-beta-D-manno-heptose + [[diphosphate]]

The enzyme is involved in [[biosynthesis]] of ADP-L-glycero-beta-D-manno-heptose.

== References ==
{{reflist}}

== External links ==
* {{MeshName|D-glycero-beta-D-manno-heptose+1-phosphate+adenylyltransferase}}

[[Category:EC 2.7.7]]