View source for AMP nucleosidase

{{enzyme
| Name = endoglycosylceramidase
| EC_number = 3.2.1.123
| CAS_number = 105503-61-5
| IUBMB_EC_number = 3/2/1/123
| GO_code = 0047876
| image = 
| width = 
| caption = 
}}
In [[enzymology]], an '''endoglycosylceramidase''' ({{EC number|3.2.1.123}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:oligoglycosylglucosylceramide + H<sub>2</sub>O <math>\rightleftharpoons</math> ceramide + oligoglycosylglucose

Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[oligoglycosylglucosylceramide]] and [[water|H<sub>2</sub>O]], whereas its two [[product (chemistry)|products]] are [[ceramide]] and [[oligoglycosylglucose]].

This enzyme belongs to the family of [[hydrolase]]s, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds.  The systematic name of this enzyme class is '''oligoglycosylglucosylceramide glycohydrolase'''. Other names in common use include '''endoglycoceramidase''', '''EGCase''', and '''glycosyl-N-acetyl-sphingosine 1,1-beta-D-glucanohydrolase'''.  

==Structural studies==

As of late 2007, 6 [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|2OSW}}, {{PDB link|2OSX}}, {{PDB link|2OSY}}, {{PDB link|2OYK}}, {{PDB link|2OYL}}, and {{PDB link|2OYM}}.

==References==
{{reflist|1}}
* {{cite journal | author = Ito M, Yamagata T | date = 1986 | title = A novel glycosphingolipid-degrading enzyme cleaves the linkage between the oligosaccharide and ceramide of neutral and acidic glycosphingolipids | journal = J. Biol. Chem.  | volume = 261 | pages = 14278&ndash;82  | pmid = 3771534 | issue = 30 }}

{{hydrolase-stub}}

[[Category:EC 3.2.1]]
[[Category:Enzymes of known structure]]