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{{Infobox enzyme
| Name = N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase
| EC_number = 2.4.1.244
| CAS_number = 
| IUBMB_EC_number = 2/4/1/244
| GO_code = 
| image = 
| width = 
| caption =
}}
'''N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase''' ({{EC number|2.4.1.244}}, ''beta1,4-N-acetylgalactosaminyltransferase III'', ''beta4GalNAc-T3'', ''beta1,4-N-acetylgalactosaminyltransferase IV'', ''beta4GalNAc-T4'', ''UDP-N-acetyl-D-galactosamine:N-acetyl-D-glucosaminyl-group beta-1,4-N-acetylgalactosaminyltransferase'') is an [[enzyme]] with system name ''UDP-N-acetyl-D-galactosamine:N-acetyl-beta-D-glucosaminyl-group 4-beta-N-acetylgalactosaminyltransferase''.<ref>{{cite journal | title = Molecular cloning and characterization of a novel human &beta;1,4-''N''-acetylgalactosaminyltransferase, &beta;4GalNAc-T3, responsible for the synthesis of ''N'',''N'''-diacetyllactosediamine, GalNAc &beta;1-4GlcNAc |author = Sato, T., Gotoh, M., Kiyohara, K., Kameyama, A., Kubota, T., Kikuchi, N., Ishizuka, Y., Iwasaki, H., Togayachi, A., Kudo, T., Ohkura, T., Nakanishi, H. and Narimatsu, H. |journal = J. Biol. Chem. |year = 2003 |volume = 278 |pages = 47534–47544 |pmid = 12966086}}</ref><ref>{{cite journal | title = Molecular cloning and characterization of &beta;1,4-''N''-acetylgalactosaminyltransferases IV synthesizing ''N'',''N'''-diacetyllactosediamine |author = Gotoh, M., Sato, T., Kiyohara, K., Kameyama, A., Kikuchi, N., Kwon, Y.D., Ishizuka, Y., Iwai, T., Nakanishi, H. and Narimatsu, H. |journal = FEBS Lett. |year = 2004 |volume = 562 |pages = 134–140 |pmid = 15044014}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: [[UDP-N-acetyl-D-galactosamine]] + N-acetyl-beta-D-glucosaminyl group <math>\rightleftharpoons</math> UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group

The enzyme from human can transfer N-acetyl-D-galactosamine (GalNAc) to [[glycan|N-glycan]] and O-glycan substrates that have [[N-acetyl-D-glucosamine]] (GlcNAc).

== References ==
{{reflist}}

== External links ==
* {{MeshName|N-acetyl-beta-glucosaminyl-glycoprotein+4-beta-N-acetylgalactosaminyltransferase}}

[[Category:EC 2.4.1]]