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{{Infobox enzyme
| Name = 1,8-Cineole 2-exo-monooxygenase
| EC_number = 1.14.13.157
| CAS_number = 
| IUBMB_EC_number = 1/14/13/157
| GO_code = 
| image = 
| width = 
| caption =
}}
'''1,8-Cineole 2-exo-monooxygenase''' ({{EC number|1.14.13.157}}, ''[[CYP3A4]]'') is an [[enzyme]] with system name ''1,8-cineole,NADPH:oxygen oxidoreductase (2-exo-hydroxylating)''.<ref>{{cite journal | title = Oxidation of 1,8-cineole, the monoterpene cyclic ether originated from ''Eucalyptus polybractea'', by cytochrome P450 3A enzymes in rat and human liver microsomes |author = Miyazawa, M., Shindo, M. and Shimada, T. |journal = Drug Metab. Dispos. |year = 2001 |volume = 29 |pages = 200–205 |pmid = 11159812 |issue=2}}</ref><ref>{{cite journal | title = Biotransformation of 1,8-cineole by human liver microsomes |author = Miyazawa, M. and Shindo, M. |journal = Nat. Prod. Lett. |year = 2001 |volume = 15 |pages = 49–53 |pmid = 11547423 |doi=10.1080/10575630108041257 |issue=1}}</ref><ref>{{cite journal | title = Roles of cytochrome ''P''<sub>450</sub> 3A enzymes in the 2-hydroxylation of 1,4-cineole, a monoterpene cyclic ether, by rat and human liver microsomes |author = Miyazawa, M., Shindo, M. and Shimada, T. |journal = Xenobiotica |year = 2001 |volume = 31 |pages = 713–723 |pmid = 11695850 |doi=10.1080/00498250110065595}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: 1,8-[[cineole]] + NADPH + H<sup>+</sup> + O<sub>2</sub> <math>\rightleftharpoons</math> 2-exo-hydroxy-1,8-cineole + NADP<sup>+</sup> + H<sub>2</sub>O

1,8-Cineole 2-exo-monooxygenase is a [[heme]]-[[thiol]]ate protein (P-450).

== References ==
{{reflist}}

== External links ==
* {{MeshName|1,8-cineole+2-exo-monooxygenase}}

[[Category:EC 1.14.13]]