View source for 8-Hydroxy-5-deazaflavin:NADPH oxidoreductase

{{Infobox enzyme
| Name = Non-specific polyamine oxidase
| EC_number = 1.5.3.17
| CAS_number = 
| IUBMB_EC_number = 1/5/3/17
| GO_code = 
| image = 
| width = 
| caption =
}}
'''Non-specific polyamine oxidase''' ({{EC number|1.5.3.17}}, ''polyamine oxidase'', ''Fms1'', ''AtPAO3'') is an [[enzyme]] with system name ''polyamine:oxygen oxidoreductase (3-aminopropanal or 3-acetamidopropanal-forming)''.<ref>{{cite journal | title = Bridging the gap between plant and mammalian polyamine catabolism: a novel peroxisomal polyamine oxidase responsible for a full back-conversion  pathway in ''Arabidopsis'' |author = Moschou, P.N., Sanmartin, M., Andriopoulou, A.H., Rojo, E., Sanchez-Serrano, J.J. and Roubelakis-Angelakis, K.A. |journal = Plant Physiol. |year = 2008 |volume = 147 |pages = 1845–1857 |pmid = 18583528 |doi=10.1104/pp.108.123802 |issue=4 |pmc=2492618}}</ref><ref>{{cite journal | title = Purification and characterization of polyamine oxidase from ''Ascaris suum'' |author = Muller, S. and Walter, R.D. |journal = Biochem. J. |year = 1992 |volume = 283 |pages = 75–80 |pmid = 1567380 |pmc=1130995}}</ref><ref>{{cite journal | title = Yeast Fms1 is a FAD-utilizing polyamine oxidase |author = Landry, J. and Sternglanz, R. |journal = Biochem. Biophys. Res. Commun. |year = 2003 |volume = 303 |pages = 771–776 |pmid = 12670477 |issue=3}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: (1) [[spermine]] + O<sub>2</sub> + H<sub>2</sub>O <math>\rightleftharpoons</math> [[spermidine]] + [[3-aminopropanal]] + H<sub>2</sub>O<sub>2</sub>
: (2) [[spermidine]] + O<sub>2</sub> + H<sub>2</sub>O <math>\rightleftharpoons</math> [[putrescine]] + 3-aminopropanal + H<sub>2</sub>O<sub>2</sub>
: (3) N<sup>1</sup>-acetylspermine + O<sub>2</sub> + H<sub>2</sub>O <math>\rightleftharpoons</math> [[spermidine]] + 3-acetamidopropanal + H<sub>2</sub>O<sub>2</sub>
: (4) N<sup>1</sup>-acetylspermidine + O<sub>2</sub> + H<sub>2</sub>O <math>\rightleftharpoons</math> [[putrescine]] + 3-acetamidopropanal + H<sub>2</sub>O<sub>2</sub>

This enzyme is flavoprotein (FAD).

== References ==
{{reflist}}

== External links ==
* {{MeshName|Non-specific+polyamine+oxidase}}

[[Category:EC 1.5.3]]