View source for 5-phosphonooxy-L-lysine phospho-lyase

{{Infobox enzyme
| Name = Phenylalanine/tyrosine ammonia-lyase
| EC_number = 4.3.1.25
| CAS_number = 
| IUBMB_EC_number = 4/3/1/25
| GO_code = 
| image = 
| width = 
| caption =
}}
'''Phenylalanine/tyrosine ammonia-lyase''' ({{EC number|4.3.1.25}}, ''PTAL'', ''bifunctional PAL'') is an [[enzyme]] with system name ''L-phenylalanine(or L-tyrosine):trans-cinnamate(or trans-p-hydroxycinnamate) ammonia-lyase''.<ref>{{cite journal | title = Maize phenylalanine ammonia-lyase has tyrosine ammonia-lyase activity |author = R&ouml;sler, J., Krekel, F., Amrhein, N. and Schmid, J. |journal = Plant Physiol. |date = 1997 |volume = 113 |pages = 175-179 |pmid = 9008393}}</ref><ref>{{cite journal | title = Discovery of a substrate selectivity switch in tyrosine ammonia-lyase, a member of the aromatic amino acid lyase family |author = Watts, K.T., Mijts, B.N., Lee, P.C., Manning, A.J. and Schmidt-Dannert, C. |journal = Chem. Biol. |date = 2006 |volume = 13 |pages = 1317-1326 |pmid = 17185227}}</ref><ref>{{cite journal | title = Structural determinants and modulation of substrate specificity in phenylalanine-tyrosine ammonia-lyases |author = Louie, G.V., Bowman, M.E., Moffitt, M.C., Baiga, T.J., Moore, B.S. and Noel, J.P. |journal = Chem. Biol. |date = 2006 |volume = 13 |pages = 1327-1338 |pmid = 17185228}}</ref><ref>{{cite journal | title = Crystal structure of histidine ammonia-lyase revealing a novel polypeptide modification as the catalytic electrophile |author = Schwede, T.F., R&eacute;tey, J. and Schulz, G.E. |journal = Biochemistry |date = 1999 |volume = 38 |pages = 5355-5361 |pmid = 10220322}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: (1) L-[[phenylalanine]] <math>\rightleftharpoons</math> [[trans-cinnamate]] + NH<sub>3</sub>
: (2) L-[[tyrosine]] <math>\rightleftharpoons</math> trans-p-hydroxycinnamate + NH<sub>3</sub>

This enzyme is a member of the aromatic amino acid lyase family.

== References ==
{{reflist}}

== External links ==
* {{MeshName|Phenylalanine/tyrosine+ammonia-lyase}}

[[Category:EC 4.3.1]]