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{{Infobox enzyme
| Name = 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase
| EC_number = 1.17.1.7
| CAS_number = 
| IUBMB_EC_number = 1/17/1/7
| GO_code = 
| image = 
| width = 
| caption =
}}
'''3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase''' ({{EC number|1.17.1.7}}, ''paaZ (gene)'') is an [[enzyme]] with system name ''3-oxo-5,6-dehydrosuberyl-CoA semialdehyde:NADP<sup>+</sup> oxidoreductase''.<ref>{{cite journal | title = Catabolism of phenylacetic acid in <em>Escherichia coli</em>. Characterization of a new aerobic hybrid pathway |author = Ferrandez, A., Minambres, B., Garcia, B., Olivera, E.R., Luengo, J.M., Garcia, J.L. and Diaz, E. |journal = J. Biol. Chem. |year = 1998 |volume = 273 |pages = 25974–25986 |pmid = 9748275 |issue=40}}</ref><ref>{{cite journal | title = Functional genomics by NMR spectroscopy. Phenylacetate catabolism in <em>Escherichia coli</em> |author = Ismail, W., El-Said Mohamed, M., Wanner, B.L., Datsenko, K.A., Eisenreich, W., Rohdich, F., Bacher, A. and Fuchs, G. |journal = Eur. J. Biochem. |year = 2003 |volume = 270 |pages = 3047–3054 |pmid = 12846838 |issue=14}}</ref><ref>{{cite journal | title = Bacterial phenylalanine and phenylacetate catabolic pathway revealed |author = Teufel, R., Mascaraque, V., Ismail, W., Voss, M., Perera, J., Eisenreich, W., Haehnel, W. and Fuchs, G. |journal = Proc. Natl. Acad. Sci. USA |year = 2010 |volume = 107 |pages = 14390–14395 |pmid = 20660314 |doi=10.1073/pnas.1005399107 |pmc=2922514}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde + NADP<sup>+</sup> + H<sub>2</sub>O <math>\rightleftharpoons</math> 3-oxo-5,6-dehydrosuberyl-CoA + NADPH + H<sup>+</sup>

The enzyme from ''[[Escherichia coli]]'' is a bifunctional protein that also acts as [[EC 3.7.1.16]], oxepin-CoA hydrolase.

== References ==
{{reflist}}

== External links ==
* {{MeshName|3-oxo-5,6-dehydrosuberyl-CoA+semialdehyde+dehydrogenase}}

[[Category:EC 1.17.1]]