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{{enzyme
| Name = alpha,alpha-trehalose-phosphate synthase (UDP-forming)
| EC_number = 2.4.1.15
| CAS_number = 9030-07-3
| IUBMB_EC_number = 2/4/1/15
| GO_code = 0003825
| image =
| width =
| caption =
}}
In [[enzymology]], an '''alpha,alpha-trehalose-phosphate synthase (UDP-forming)''' ({{EC number|2.4.1.15}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:UDP-glucose + D-glucose 6-phosphate <math>\rightleftharpoons</math> UDP + alpha,alpha-trehalose 6-phosphate

Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[UDP-glucose]] and [[D-glucose 6-phosphate]], whereas its two [[product (chemistry)|products]] are [[uridine diphosphate|UDP]] and [[alpha,alpha'-trehalose 6-phosphate]].

This enzyme belongs to the family of [[glycosyltransferase]]s, specifically the hexosyltransferases.  The systematic name of this enzyme class is '''UDP-glucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase'''. Other names in common use include '''UDP-glucose-glucose-phosphate glucosyltransferase''', '''trehalosephosphate-UDP glucosyltransferase''', '''UDP-glucose-glucose-phosphate glucosyltransferase''', '''alpha,alpha-trehalose phosphate synthase (UDP-forming)''', '''phosphotrehalose-uridine diphosphate transglucosylase''', '''trehalose 6-phosphate synthase''', '''trehalose 6-phosphate synthetase''', '''trehalose phosphate synthase''', '''trehalose phosphate synthetase''', '''trehalose phosphate-uridine diphosphate glucosyltransferase''', '''trehalose-P synthetase''', '''transglucosylase''', and '''uridine diphosphoglucose phosphate glucosyltransferase'''.  This enzyme participates in [[starch and sucrose metabolism]]. 

==Structural studies==
As of late 2007, 3 [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|1GZ5}}, {{PDB link|1UQT}}, and {{PDB link|1UQU}}.

==References==
{{reflist|1}}
* {{cite journal | author = CABIB E, LELOIR LF | date = 1958 | title = The biosynthesis of trehalose phosphate | journal = J. Biol. Chem.  | volume = 231 | pages = 259&ndash;75  | pmid = 13538966 | issue = 1 }}
* {{cite journal | author = CANDY DJ, KILBY BA | date = 1961 | title = The biosynthesis of trehalose in the locust fat body | journal = Biochem. J.  | volume = 78 | pages = 531&ndash;6  | pmid = 13690400 | pmc = 1205371 }}
* {{cite journal | author = LORNITZO FA, GOLDMAN DS | date = 1964 | title = PURIFICATION AND PROPERTIES OF THE TRANSGLUCOSYLASE INHIBITOR OF MYCOBACTERIUM TUBERCULOSIS | journal = J. Biol. Chem.  | volume = 239 | pages = 2730&ndash;4  | pmid = 14216421 }}
* {{cite journal | author = MURPHY TA, WYATT GR | date = 1965 | title = THE ENZYMES OF GLYCOGEN AND TREHALOSE SYNTHESIS IN SILK MOTH FAT BODY | journal = J. Biol. Chem.  | volume = 240 | pages = 1500&ndash;8  | pmid = 14285483 }}

[[Category:EC 2.4.1]]
[[Category:Enzymes of known structure]]

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