View source for 4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase

{{enzyme
| Name = 6-oxohexanoate dehydrogenase
| EC_number = 1.2.1.63
| CAS_number = 
| IUBMB_EC_number = 1/2/1/63
| GO_code = 0018483
| image = 
| width = 
| caption = 
}}
In [[enzymology]], a '''6-oxohexanoate dehydrogenase''' ({{EC number|1.2.1.63}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:6-oxohexanoate + NADP<sup>+</sup> + H<sub>2</sub>O <math>\rightleftharpoons</math> adipate + NADPH + 2 H<sup>+</sup>

The 3 [[substrate (biochemistry)|substrates]] of this enzyme are [[6-oxohexanoate]], [[nicotinamide adenine dinucleotide phosphate|NADP<sup>+</sup>]], and [[water|H<sub>2</sub>O]], whereas its 3 [[product (chemistry)|products]] are [[adipate]], [[nicotinamide adenine dinucleotide phosphate|NADPH]], and [[hydrogen ion|H<sup>+</sup>]].

This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor.  The systematic name of this enzyme class is '''6-oxohexanoate:NADP+ oxidoreductase'''. This enzyme participates in [[caprolactam degradation]].  

==References==
{{reflist|1}}
* {{cite journal | author = Davey JF, Trudgill PW | date = 1977 | title = The metabolism of trans-cyclohexan-1,2-diol by an Acinetobacter species | journal = Eur. J. Biochem.  | volume = 74 | pages = 115&ndash;27  | pmid = 856571 | doi = 10.1111/j.1432-1033.1977.tb11373.x | issue = 1 }}
* {{cite journal | author = Donoghue NA, Trudgill PW | date = 1975 | title = The metabolism of cyclohexanol by Acinetobacter NCIB 9871 | journal = Eur. J. Biochem.  | volume = 60 | pages = 1&ndash;7  | pmid = 1261 | doi = 10.1111/j.1432-1033.1975.tb20968.x | issue = 1 }}

{{1.2-enzyme-stub}}

[[Category:EC 1.2.1]]
[[Category:NADPH-dependent enzymes]]
[[Category:Enzymes of unknown structure]]