View source for 3-alpha,7-alpha-dihydroxy-5-beta-cholestanate—CoA ligase

{{enzyme
| Name = acetate-CoA ligase (ADP-forming)
| EC_number = 6.2.1.13
| CAS_number = 62009-85-2
| IUBMB_EC_number = 6/2/1/13
| GO_code = 0043758
| image = 
| width = 
| caption = 
}}
In [[enzymology]], an '''acetate-CoA ligase (ADP-forming)''' ({{EC number|6.2.1.13}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:ATP + acetate + CoA <math>\rightleftharpoons</math> ADP + phosphate + acetyl-CoA

The 3 [[substrate (biochemistry)|substrates]] of this enzyme are [[adenosine triphosphate|ATP]], [[acetate]], and [[coenzyme A|CoA]], whereas its 3 [[product (chemistry)|products]] are [[adenosine diphosphate|ADP]], [[phosphate]], and [[acetyl-CoA]].

This enzyme belongs to the family of [[ligase]]s, specifically those forming carbon-sulfur bonds as acid-thiol ligases.  The systematic name of this enzyme class is '''acetate:CoA ligase (ADP-forming)'''. Other names in common use include '''acetyl-CoA synthetase (ADP-forming)''', '''acetyl coenzyme A synthetase (adenosine diphosphate-forming)''', and '''acetate thiokinase'''.  This enzyme participates in [[pyruvate metabolism]] and [[propanoate metabolism]].

==References==
{{reflist|1}}
* {{cite journal | author = Reeves RE, Warren LG, Susskind B, Lo HS | year = 1977 | title = An energy-conserving pyruvate-to-acetate pathway in Entamoeba histolytica. Pyruvate synthase and a new acetate thiokinase | journal = J. Biol. Chem.  | volume = 252 | pages = 726&ndash;31  | pmid = 13076 | issue = 2 }}

{{DEFAULTSORT:Acetate-CoA ligase (ADP-forming)}}
[[Category:EC 6.2.1]]
[[Category:Enzymes of unknown structure]]


{{ligase-stub}}