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{{Infobox enzyme
| Name = Cobalt-precorrin-7 (C<sup>15</sup>)-methyltransferase (decarboxylating)
| EC_number = 2.1.1.196
| CAS_number = 
| IUBMB_EC_number = 2/1/1/196
| GO_code = 
| image = 
| width = 
| caption =
}}
'''Cobalt-precorrin-7 (C<sup>15</sup>)-methyltransferase (decarboxylating)''' ({{EC number|2.1.1.196}}, ''CbiT'') is an [[enzyme]] with system name ''S-adenosyl-L-methionine:precorrin-7 C<sup>15</sup>-methyltransferase (C-12-decarboxylating)''.<ref>{{cite journal | title = The crystal structure of MT0146/CbiT suggests that the putative precorrin-8w decarboxylase is a methyltransferase |author = Keller, J.P., Smith, P.M., Benach, J., Christendat, D., deTitta, G.T. and Hunt, J.F. |journal = Structure |year = 2002 |volume = 10 |pages = 1475–1487 |pmid = 12429089 | doi = 10.1016/S0969-2126(02)00876-6 | issue = 11}}</ref><ref>{{cite journal | title = Structural characterization of novel cobalt corrinoids synthesized by enzymes of the vitamin B<sub>12</sub> anaerobic pathway |author = Santander, P.J., Kajiwara, Y., Williams, H.J. and Scott, A.I. |journal = Bioorg. Med. Chem. |year = 2006 |volume = 14 |pages = 724–731 |pmid = 16198574 | doi = 10.1016/j.bmc.2005.08.062 | issue = 3}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: [[cobalt-precorrin-7]] + [[S-adenosyl-L-methionine]] <math>\rightleftharpoons</math> cobalt-precorrin-8x + [[S-adenosyl-L-homocysteine]] + CO<sub>2</sub>

This enzyme catalyses both [[methylation]] at C-15 and [[decarboxylation]] of the C-12 [[acetate]] side chain of cobalt-precorrin-7.

== References ==
{{reflist}}

== External links ==
*{{MeshName|Cobalt-precorrin-7+(C15)-methyltransferase+(decarboxylating)}}

[[Category:EC 2.1.1]]