View source for 21S rRNA (uridine2791-2'-O)-methyltransferase

{{Infobox enzyme
| Name = 16S rRNA (adenine<sup>1408</sup>-N<sup>1</sup>)-methyltransferase
| EC_number = 2.1.1.180
| CAS_number = 
| IUBMB_EC_number = 2/1/1/180
| GO_code = 
| image = 
| width = 
| caption =
}}
'''16S rRNA (adenine<sup>1408</sup>-N<sup>1</sup>)-methyltransferase''' ({{EC number|2.1.1.180}}, ''kanamycin-apramycin resistance methylase'', ''16S rRNA:m1A1408 methyltransferase'', ''KamB'', ''NpmA'', ''16S rRNA m1A1408 methyltransferase'') is an [[enzyme]] with system name ''S-adenosyl-L-methionine:16S rRNA (adenine<sup>1408</sup>-N<sup>1</sup>)-methyltransferase''.<ref>{{cite journal | title = Sites of action of two ribosomal RNA methylases responsible for resistance to aminoglycosides |author = Beauclerk, A.A. and Cundliffe, E. |journal = J. Mol. Biol. |year = 1987 |volume = 193 |pages = 661–671 |pmid = 2441068}}</ref><ref>{{cite journal | title = Identification of a missing sequence and functionally important residues of 16S rRNA:m<sup>1</sup>A<sup>1408</sup> methyltransferase KamB that causes bacterial  resistance to aminoglycoside antibiotics |author = Koscinski, L., Feder, M. and Bujnicki, J.M. |journal = Cell Cycle |year = 2007 |volume = 6 |pages = 1268–1271 |pmid = 17495534}}</ref><ref>{{cite journal | title = Cloning of an aminoglycoside-resistance-encoding gene, ''kamC'', from ''Saccharopolyspora hirsuta'': comparison with ''kamB'' from ''Streptomyces tenebrarius'' |author = Holmes, D.J., Drocourt, D., Tiraby, G. and Cundliffe, E. |journal = Gene |year = 1991 |volume = 102 |pages = 19–26 |pmid = 1840536}}</ref><ref>{{cite journal | title = Novel plasmid-mediated 16S rRNA m<sup>1</sup>A<sup>1408</sup> methyltransferase, NpmA, found in a clinically isolated ''Escherichia coli'' strain resistant to structurally  diverse aminoglycosides |author = Wachino, J., Shibayama, K., Kurokawa, H., Kimura, K., Yamane, K., Suzuki, S., Shibata, N., Ike, Y. and Arakawa, Y. |journal = Antimicrob. Agents Chemother. |year = 2007 |volume = 51 |pages = 4401–4409 |pmid = 17875999}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: [[S-adenosyl-L-methionine]] + [[adenine]]<sup>1408</sup> in [[Ribosomal RNA|16S rRNA]] <math>\rightleftharpoons</math> [[S-adenosyl-L-homocysteine]] + N<sup>1</sup>-[[methyladenine]]<sup>1408</sup> in 16S rRNA

The enzyme provides a [[panaminoglycosid]]e resistance through interference with the binding of [[aminoglycoside]]s.

== References ==
{{reflist}}

== External links ==
* {{MeshName|16S+rRNA+(adenine1408-N1)-methyltransferase}}

[[Category:EC 2.1.1]]