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{{Infobox enzyme
| Name = Acireductone synthase
| EC_number = 3.1.3.77
| CAS_number = 
| IUBMB_EC_number = 3/1/3/77
| GO_code = 
| image = 
| width = 
| caption =
}}
'''Acireductone synthase''' ({{EC number|3.1.3.77}}, ''E1'', ''E-1 enolase-phosphatase'') is an [[enzyme]] with system name ''5-(methylthio)-2,3-dioxopentyl-phosphate phosphohydrolase (isomerizing)''.<ref>{{cite journal | title = Purification and characterization of an enzyme involved in oxidative carbon-carbon bond cleavage reactions in the methionine salvage pathway of  <em>Klebsiella pneumoniae</em> |author = Myers, R.W., Wray, J.W., Fish, S. and Abeles, R.H. |journal = J. Biol. Chem. |year = 1993 |volume = 268 |pages = 24785–24791 |pmid = 8227039 |issue=33}}</ref><ref>{{cite journal | title = The methionine salvage pathway in <em>Klebsiella pneumoniae</em> and rat liver. Identification and characterization of two novel dioxygenases |author = Wray, J.W. and Abeles, R.H. |journal = J. Biol. Chem. |year = 1995 |volume = 270 |pages = 3147–3153 |pmid = 7852397 |doi=10.1074/jbc.270.7.3147}}</ref><ref>{{cite journal | title = Crystal structure of human E1 enzyme and its complex with a substrate analog reveals the mechanism of its phosphatase/enolase activity |author = Wang, H., Pang, H., Bartlam, M. and Rao, Z. |journal = J. Mol. Biol. |year = 2005 |volume = 348 |pages = 917–926 |pmid = 15843022 |doi=10.1016/j.jmb.2005.01.072 |issue=4}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: 5-(methylthio)-2,3-dioxopentyl phosphate + H<sub>2</sub>O <math>\rightleftharpoons</math> 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + [[phosphate]] (overall reaction)
:(1a) 5-(methylthio)-2,3-dioxopentyl phosphate <math>\rightleftharpoons</math> 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate (probably spontaneous)
:(1b) 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate + H<sub>2</sub>O <math>\rightleftharpoons</math> 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate

== References ==
{{reflist}}

== External links ==
* {{MeshName|Acireductone+synthase}}

[[Category:EC 3.1.3]]