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{{enzyme
| Name = Adenylyl-sulfate reductase (glutathione)
| EC_number = 1.8.4.9
| CAS_number = 
| IUBMB_EC_number = 1/8/4/9
| GO_code = 
| image = 
| width = 
| caption = 
}}
'''Adenylyl-sulfate reductase (glutathione)''' ({{EC number|1.8.4.9}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:AMP + sulfite + glutathione disulfide <math>\rightleftharpoons</math> adenylyl sulfate + 2 glutathione

The 3 [[substrate (biochemistry)|substrates]] of this enzyme are [[adenosine monophosphate]], [[sulfite]], and [[glutathione disulfide]], whereas its two [[product (chemistry)|products]] are [[adenylyl sulfate]] and [[glutathione]].

This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on a sulfur group of donors with a disulfide as acceptor.  The systematic name of this enzyme class is '''AMP,sulfite:glutathione-disulfide oxidoreductase (adenosine-5'-phosphosulfate-forming)'''. Other names in common use include '''5'-adenylylsulfate reductase (also used for''', '''internal_xref(ec_num(1,8,99,2)))''', '''AMP,sulfite:oxidized-glutathione oxidoreductase''', '''(adenosine-5'-phosphosulfate-forming)''', and '''plant-type 5'-adenylylsulfate reductase'''.  

==References==
{{reflist|1}}
* {{cite journal | author = Gutierrez-Marcos JF, Roberts MA, Campbell EI, Wray JL | date = 1996 | title = Three members of a novel small gene-family from Arabidopsis thaliana able to complement functionally an Escherichia coli mutant defective in PAPS reductase activity encode proteins with a thioredoxin-like domain and "APS reductase" activity | journal = Proc. Natl. Acad. Sci. U.S.A.  | volume = 93 | pages = 13377–82  | pmid = 8917599 | doi = 10.1073/pnas.93.23.13377 | issue = 23 | pmc = 24101 }}
* {{cite journal | author = Setya A, Murillo M, Leustek T | date = 1996 | title = Sulfate reduction in higher plants: Molecular evidence for a novel 5′-adenylylsulfate reductase | journal = Proc. Natl. Acad. Sci. U.S.A.  | volume = 93 | pages = 13383–8  | pmid = 8917600 | doi = 10.1073/pnas.93.23.13383 | issue = 23 | pmc = 24102 }}
* {{cite journal | author = Bick JA, Aslund F, Chen Y, Leustek T | date = 1998 | title = Glutaredoxin function for the carboxyl-terminal domain of the plant-type 5′-adenylylsulfate reductase | journal = Proc. Natl. Acad. Sci. U.S.A.  | volume = 95 | pages = 8404–9  | pmid = 9653199 | doi = 10.1073/pnas.95.14.8404 | issue = 14 | pmc = 20988 }}

[[Category:EC 1.8.4]]
[[Category:Enzymes of unknown structure]]