View source for 2-deoxy-D-gluconate 3-dehydrogenase

{{enzyme
| Name = 3-alpha-hydroxycholanate dehydrogenase
| EC_number = 1.1.1.52
| CAS_number = 9028-57-3
| IUBMB_EC_number = 1/1/1/52
| GO_code = 0047043
| image = 
| width = 
| caption = 
}}
In [[enzymology]], a '''3alpha-hydroxycholanate dehydrogenase''' ({{EC number|1.1.1.52}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:3alpha-hydroxy-5beta-cholanate + NAD<sup>+</sup> <math>\rightleftharpoons</math> 3-oxo-5beta-cholanate + NADH + H<sup>+</sup>

Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[3alpha-hydroxy-5beta-cholanate]] and [[nicotinamide adenine dinucleotide|NAD<sup>+</sup>]], whereas its 3 [[product (chemistry)|products]] are [[3-oxo-5beta-cholanate]], [[nicotinamide adenine dinucleotide|NADH]], and [[hydrogen ion|H<sup>+</sup>]].

This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on the CH-OH group of donor with NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor. The systematic name of this enzyme class is '''3alpha-hydroxy-5beta-cholanate:NAD<sup>+</sup> oxidoreductase'''. This enzyme is also called '''alpha-hydroxy-cholanate dehydrogenase'''.

==Structural studies==

As of late 2007, only one [[tertiary structure|structure]] has been solved for this class of enzymes, with the [[Protein Data Bank|PDB]] accession code {{PDB link|1IHI}}.

==References==
{{reflist|1}}
* {{cite journal | author = Hayaishi O, Sato Y, Jakoby WB, Stohlman EF | date = 1955 | title = Reversible enzymatic oxidation of bile acids | journal = Arch. Biochem. | volume = 56 | pages = 554&ndash;5 | pmid = 14377608 | doi = 10.1016/0003-9861(55)90278-2 | issue = 2 }}


[[Category:EC 1.1.1]]
[[Category:NADH-dependent enzymes]]
[[Category:Enzymes of known structure]]


{{1.1.1-enzyme-stub}}