Ornithine(lysine) transaminase

2013-01-28T18:51:39Z

138.202.150.157:

{{enzyme
| Name = succinylornithine transaminase
| EC_number = 2.6.1.81
| CAS_number =
| IUBMB_EC_number = 2/6/1/81
| GO_code = 0043825
| image =
| width =
| caption =
}}

In [[enzymology]], a '''succinylornithine transaminase''' ({{EC number|2.6.1.81}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:N<sub>2</sub>-succinyl-L-ornithine + 2-oxoglutarate <math>\rightleftharpoons</math> N-succinyl-L-glutamate 5-semialdehyde + L-glutamate

Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[N2-succinyl-L-ornithine]] and [[2-oxoglutarate]], whereas its two [[product (chemistry)|products]] are [[N-succinyl-L-glutamate 5-semialdehyde]] and [[L-glutamate]].

This enzyme belongs to the family of [[transferase]]s, specifically the [[transaminases]], which transfer nitrogenous groups. The systematic name of this enzyme class is '''N2-succinyl-L-ornithine:2-oxoglutarate 5-aminotransferase'''. Other names in common use include '''succinylornithine aminotransferase''', '''N2-succinylornithine 5-aminotransferase''', '''AstC''', '''SOAT''', and '''2-N-succinyl-L-ornithine:2-oxoglutarate 5-aminotransferase'''. This enzyme participates in [[arginine and proline metabolism]].

==References==
{{reflist|1}}
* {{cite journal | author = Vander Wauven C, Stalon V | date = 1985 | title = Occurrence of succinyl derivatives in the catabolism of arginine in Pseudomonas cepacia | journal = J. Bacteriol. | volume = 164 | pages = 882–6 | pmid = 2865249 | issue = 2 | pmc = 214334 }}
* {{cite journal | author = Schneider BL, Kiupakis AK, Reitzer LJ | date = 1998 | title = Arginine catabolism and the arginine succinyltransferase pathway in Escherichia coli | journal = J. Bacteriol. | volume = 180 | pages = 4278–86 | pmid = 9696779 | issue = 16 | pmc = 107427 }}
* {{cite journal | author = Cunin R, Glansdorff N, Pierard A, Stalon V | date = 1986 | title = Biosynthesis and metabolism of arginine in bacteria | journal = Microbiol. Rev. | volume = 50 | pages = 314–52 | pmid = 3534538 | issue = 3 | pmc = 373073 }}
* {{cite journal | author = Itoh Y | date = 1997 | title = Cloning and characterization of the aru genes encoding enzymes of the catabolic arginine succinyltransferase pathway in Pseudomonas aeruginosa | journal = J. Bacteriol. | volume = 179 | pages = 7280–90 | pmid = 9393691 | issue = 23 | pmc = 179677 }}
* {{cite journal | author = Stalon V, Vander Wauven C, Momin P, Legrain C | date = 1987 | title = Catabolism of arginine, citrulline and ornithine by Pseudomonas and related bacteria | journal = J. Gen. Microbiol. | volume = 133 | pages = 2487–95 | pmid = 3129535 | issue = 9 }}

{{transferase-stub}}

[[Category:EC 2.6.1]]
[[Category:Enzymes of unknown structure]]

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Ornithine(lysine) transaminase